Tuberculous meningitis: pathogenesis, immune responses, diagnostic challenges, and the potential of biomarker-based approaches
Tuberculous meningitis (TBM) is the most devastating form of tuberculosis (TB), causing
high mortality or disability. Clinical management of the disease is challenging due to …
high mortality or disability. Clinical management of the disease is challenging due to …
Central nervous system tuberculosis
Recent studies in the field of CNS-TB have largely focussed on TB meningitis. The outcome
may improve by optimizing treatment dosing. This needs to be confirmed in clinical trials …
may improve by optimizing treatment dosing. This needs to be confirmed in clinical trials …
[HTML][HTML] Single-cell analysis reveals changes in BCG vaccine-injected mice modeling tuberculous meningitis brain infection
X Zhang, Z Zhao, Q Wu, L Wang, L Li, M Wang, Y Ren… - Cell Reports, 2023 - cell.com
Tuberculous meningitis (TBM) is the most severe and deadly manifestation of tuberculosis.
Neurological complications are observed in up to 50% of patients affected. Here, attenuated …
Neurological complications are observed in up to 50% of patients affected. Here, attenuated …
The use of thalidomide to treat children with tuberculosis meningitis: a review
R Van Toorn, SD Zaharie, JA Seddon, M van der Kuip… - Tuberculosis, 2021 - Elsevier
Much of the morbidity and mortality caused by tuberculous meningitis (TBM) is mediated by
a dysregulated immune response. Effective host-directed therapy is therefore critical to …
a dysregulated immune response. Effective host-directed therapy is therefore critical to …
[HTML][HTML] Recent advances in understanding the human host immune response in tuberculous meningitis
JR Barnacle, AG Davis, RJ Wilkinson - Frontiers in Immunology, 2024 - frontiersin.org
Tuberculous meningitis (TBM), the most severe form of tuberculosis, causes death in
approximately 25% cases despite antibiotic therapy, and half of survivors are left with …
approximately 25% cases despite antibiotic therapy, and half of survivors are left with …
[HTML][HTML] Recent developments in tuberculous meningitis pathogenesis and diagnostics
The pathogenesis of Tuberculous meningitis (TBM) is poorly understood, but contemporary
molecular biology technologies have allowed for recent improvements in our understanding …
molecular biology technologies have allowed for recent improvements in our understanding …
[HTML][HTML] The changes and its significance of peripheral blood NK cells in patients with tuberculous meningitis
J Mi, Y Liu, Y Xue, W Sun, Y Liang, J Liang… - Frontiers in …, 2024 - frontiersin.org
Objective Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB). The
purpose of this study was to explore the relationship between the number of natural killer …
purpose of this study was to explore the relationship between the number of natural killer …
[HTML][HTML] Thalidomide and phosphodiesterase 4 inhibitors as host directed therapeutics for tuberculous meningitis: insights from the rabbit model
Tuberculous meningitis (TBM) is the most devastating form of extrapulmonary
Mycobacterium tuberculosis infection in humans. Severe inflammation and extensive tissue …
Mycobacterium tuberculosis infection in humans. Severe inflammation and extensive tissue …
[HTML][HTML] CNS tuberculosis
M Gupta, S Munakomi - 2022 - europepmc.org
Objectives: Identify the global epidemiology of CNS tuberculosis. Describe the various
clinical presentations of a patient with CNS tuberculosis. Outline the diagnosis and …
clinical presentations of a patient with CNS tuberculosis. Outline the diagnosis and …
[HTML][HTML] Myelitis: a common complication of tuberculous meningitis predicting poor outcome
Y Jiang, X Xu, Z Guo, Y Liu, J Lin, L Suo… - Frontiers in …, 2022 - frontiersin.org
Background Myelitis is an important complication in patients with tuberculous meningitis
(TBM). However, a paucity of publications exists on the spectrum of neurological and MRI …
(TBM). However, a paucity of publications exists on the spectrum of neurological and MRI …