[HTML][HTML] Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Context-specific regulation and function of mRNA alternative polyadenylation
S Mitschka, C Mayr - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
PolyASite 2.0: a consolidated atlas of polyadenylation sites from 3′ end sequencing
CJ Herrmann, R Schmidt, A Kanitz, P Artimo… - Nucleic acids …, 2020 - academic.oup.com
Generated by 3′ end cleavage and polyadenylation at alternative polyadenylation (poly
(A)) sites, alternative terminal exons account for much of the variation between human …
(A)) sites, alternative terminal exons account for much of the variation between human …
Multiplexed single-cell characterization of alternative polyadenylation regulators
Most mammalian genes have multiple polyA sites, representing a substantial source of
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …
transcript diversity regulated by the cleavage and polyadenylation (CPA) machinery. To …
Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
Cleavage and polyadenylation (CPA) is responsible for 3′ end processing of eukaryotic
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
poly (A)+ RNAs and preludes transcriptional termination. JTE-607, which targets CPSF-73 …
RNA-binding proteins balance brain function in health and disease
R Schieweck, J Ninkovic… - Physiological reviews, 2021 - journals.physiology.org
Posttranscriptional gene expression including splicing, RNA transport, translation, and RNA
decay provides an important regulatory layer in many if not all molecular pathways …
decay provides an important regulatory layer in many if not all molecular pathways …
Regulation of alternative polyadenylation by the C2H2-zinc-finger protein Sp1
Alternative polyadenylation (APA) enhances gene regulatory potential by increasing the
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …
diversity of mRNA transcripts. 3′ UTR shortening through APA correlates with enhanced …
Selective roles of vertebrate PCF11 in premature and full-length transcript termination
K Kamieniarz-Gdula, MR Gdula, K Panser, T Nojima… - Molecular cell, 2019 - cell.com
The pervasive nature of RNA polymerase II (Pol II) transcription requires efficient
termination. A key player in this process is the cleavage and polyadenylation (CPA) factor …
termination. A key player in this process is the cleavage and polyadenylation (CPA) factor …
Emerging roles of the MAGE protein family in stress response pathways
The melanoma antigen (MAGE) proteins all contain a MAGE homology domain. MAGE
genes are conserved in all eukaryotes and have expanded from a single gene in lower …
genes are conserved in all eukaryotes and have expanded from a single gene in lower …
[HTML][HTML] Alternative polyadenylation of mRNA and its role in cancer
Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′
end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from …
end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from …