Therapeutics for neurodegenerative diseases by targeting the gut microbiome: from bench to bedside

YY Ma, X Li, JT Yu, YJ Wang - Translational Neurodegeneration, 2024 - Springer
The aetiologies and origins of neurodegenerative diseases, such as Alzheimer's disease
(AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and Huntington's …

Vitamin D, a secosteroid hormone and its multifunctional receptor, vitamin D receptor, in Alzheimer's type neurodegeneration

D Gezen-Ak, E Dursun - J Alzheimers Dis, 2023 - content.iospress.com
Vitamin D is a secosteroid hormone exerting neurosteroid-like properties. Its well-known
nuclear hormone receptor, and recently proposed as a mitochondrial transcription factor …

[PDF][PDF] Molecular Regulation of the CNS by Vitamin D.

L MÁČOVÁ, R KANCHEVA, M BIČÍKOVÁ - Physiological Research, 2023 - biomed.cas.cz
Vitamin D is a lipid-soluble vitamin that can be found in some foods. It is also produced
endogenously (in the presence of ultraviolet light), transported through the blood to the …

[HTML][HTML] PEA-OXA restores cognitive impairments associated with vitamin D deficiency-dependent alterations of the gut microbiota

F Guida, M Iannotta, M Perrone, R Infantino… - Biomedicine & …, 2024 - Elsevier
There is a growing evidence suggesting the association of vitamin D deficiency (VDD) and
cognitive impairment. In this study we evaluated the possible involvement of gut microbiota …

Molecular Aspects of a Diet as a New Pathway in the Prevention and Treatment of Alzheimer's Disease

J Doroszkiewicz, J Mroczko, P Rutkowski… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease is the most common cause of dementia in the world. Lack of an
established pathology makes it difficult to develop suitable approaches and treatment for the …

Protective effect of cholecalciferol against cobalt-induced neurotoxicity in rats: ZO-1/iFABP, ChAT/AchE and antioxidant pathways as potential therapeutic targets

AS Akinrinde, BO Adeoye, ES Samuel… - … Trace Element Research, 2024 - Springer
Cobalt (Co) toxicity has been reported to produce central nervous system and
gastrointestinal abnormalities. This study assessed the therapeutic effect of cholecalciferol …

Rare-variant collapsing and bioinformatic analyses for amyloidosis, dementia and Parkinson's disease in the UK biobank reveal novel susceptibility loci

B Zöller, E Manderstedt, C Lind-Halldén, C Halldén - Amyloid, 2023 - Taylor & Francis
Amyloidosis is a group of rare diseases in which soluble proteins aggregate and deposit
extracellularly in tissues as insoluble amyloid fibrils, causing organ dysfunction [1]. This …

Der Einfluss von Vitamin D und seinen Analoga auf die in der Alzheimer-Demenz relevante Aβ-Homöostase

A Thiel - 2023 - publikationen.sulb.uni-saarland.de
Die neurodegenerative Erkrankung Morbus Alzheimer gewinnt aufgrund ihrer steigenden
Prävalenz zunehmend an klinischer, sozialer und wirtschaftlicher Relevanz. Eine …