Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the
nuclear DNA. As such, variations in nuclear gene expression as a consequence of …

The mitochondrion is an intracellular organelle thought to originate from endosymbiosis
between an ancestral eukaryotic cell and an α-proteobacterium. Mitochondria are the …

Mitochondrial DNA (mtDNA) variation in common diseases has been underexplored, partly
due to a lack of genotype calling and quality-control procedures. Developing an at-scale …

Mitochondria are cytoplasmic organelles, which generate energy as heat and ATP, the
universal energy currency of the cell. This process is carried out by coupling electron …

Mitochondria are well known as 'the powerhouses of the cell'. Indeed, their major role is
cellular energy production driven by both mitochondrial and nuclear DNA. Such a feature …

The first draft human mitochondrial DNA (mtDNA) sequence was published in 1981, paving
the way for two decades of discovery linking mtDNA variation with human disease. Severe …

Mitochondrial (MT) dysfunction is a hallmark of aging and has been associated with most
aging-related diseases as well as immunological processes. However, little is known about …

Mitochondrial DNA (mtDNA) variants influence the risk of late-onset human diseases, but the
reasons for this are poorly understood. Undertaking a hypothesis-free analysis of 5,689 …

In human beings, there is a∼ 16,569 bp circular mitochondrial DNA (mtDNA) encoding 22
tRNAs, 12S and 16S rRNAs, 13 polypeptides that constitute the central core of ETC/OxPhos …

Mitochondria harbor multiple copies of a maternally inherited nonnuclear genome. Point
mutations, deletions, or depletion of the mitochondrial DNA (mtDNA) are associated with …