Understanding the antioxidant and carbonyl sequestering activity of carnosine: Direct and indirect mechanisms

G Aldini, B de Courten, L Regazzoni… - Free radical …, 2021 - Taylor & Francis
Carnosine is an endogenous dipeptide whose oral administration has been found to prevent
several oxidative based diseases including lung disease, type 2 diabetes and its micro and …

Can the skeletal muscle carnosine response to beta-alanine supplementation be optimized?

P Perim, FM Marticorena, F Ribeiro, G Barreto… - Frontiers in …, 2019 - frontiersin.org
Carnosine is an abundant histidine-containing dipeptide in human skeletal muscle and
formed by beta-alanine and L-histidine. It performs various physiological roles during …

[PDF][PDF] Relationship between skeletal muscle carnosine content and cycling sprint performance

LF de Oliveira, RP da Silva… - Journal of Science …, 2019 - jsc-journal.com
Purpose: High-intensity exercise is limited by muscle acidosis, among other factors.
Supplementation with buffering agents can delay the onset of muscular fatigue and improve …

[HTML][HTML] Physiological roles of carnosine in myocardial function and health

JV Creighton, L de Souza Gonçalves, GG Artioli… - Advances in …, 2022 - Elsevier
Carnosine is a pleiotropic histidine-containing dipeptide synthesized from β-alanine and l-
histidine, with the intact dipeptide and constituent amino acids being available from the diet …

[HTML][HTML] A systematic risk assessment and meta-analysis on the use of oral β-alanine supplementation

E Dolan, PA Swinton, V de Salles Painelli… - Advances in …, 2019 - Elsevier
ABSTRACT β-Alanine supplementation is one of the world's most commonly used sports
supplements, and its use as a nutritional strategy in other populations is ever-increasing …

[HTML][HTML] Effect of carnosine or β-alanine supplementation on markers of glycemic control and insulin resistance in humans and animals: a systematic review and meta …

JJ Matthews, E Dolan, PA Swinton, L Santos… - Advances in …, 2021 - Elsevier
There is growing evidence that supplementation with carnosine, or its rate-limiting precursor
β-alanine, can ameliorate aspects of metabolic dysregulation that occur in diabetes and its …

The muscle carnosine response to beta-alanine supplementation: a systematic review with Bayesian individual and aggregate data E-max model and meta-analysis

NS Rezende, P Swinton, LF de Oliveira… - Frontiers in …, 2020 - frontiersin.org
Beta-alanine (BA) supplementation increases muscle carnosine content (MCarn), and has
many proven, and purported, ergogenic, and therapeutic benefits. Currently, many questions …

Extensive profiling of histidine‐containing dipeptides reveals species‐and tissue‐specific distribution and metabolism in mice, rats, and humans

T Van der Stede, J Spaas, S de Jager… - Acta …, 2023 - Wiley Online Library
Abstract Aim Histidine‐containing dipeptides (HCDs) are pleiotropic homeostatic molecules
with potent antioxidative and carbonyl quenching properties linked to various inflammatory …

Efficacy of 12 weeks oral beta‐alanine supplementation in patients with chronic obstructive pulmonary disease: a double‐blind, randomized, placebo‐controlled trial

J De Brandt, W Derave, F Vandenabeele… - Journal of cachexia …, 2022 - Wiley Online Library
Background Beta‐alanine (BA) supplementation increases muscle carnosine, an abundant
endogenous antioxidant and pH buffer in skeletal muscle. Carnosine loading promotes …

The physiological roles of carnosine and β-alanine in exercising human skeletal muscle

JJ Matthews, GG Artioli, MD Turner… - Medicine & Science in …, 2019 - open-access.bcu.ac.uk
Carnosine (β-alanyl-L-histidine) plays an important role in exercise performance and
skeletalmuscle homeostasis. Dietary supplementation with the rate-limiting precursor β …