At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

Biological structures span many orders of magnitude in size, but far-field visible light
microscopy suffers from limited resolution. A new method for fluorescence imaging has been …

Cholesterol is an essential structural component in the cell membranes of most vertebrates.
The biophysical properties of cholesterol and the enzymology of cholesterol metabolism …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Phagocytic receptors must diffuse laterally to become activated upon clustering by
multivalent targets. Receptor diffusion, however, can be obstructed by transmembrane …

▪ Abstract Recent advancements in single-molecule tracking methods with nanometer-level
precision now allow researchers to observe the movement, recruitment, and activation of …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

The axon initial segment (AIS) is a specialized region in neurons where action potentials are
initiated. It is commonly assumed that this process requires a high density of voltage-gated …

The axon initial segment (AIS) is located at the proximal axon and is the site of action
potential initiation. This reflects the high density of ion channels found at the AIS. Adaptive …