Automatic reuse, adaption, and execution of simulation experiments via provenance patterns
Simulation experiments are typically conducted repeatedly during the model development
process, for example, to revalidate if a behavioral property still holds after several model …
process, for example, to revalidate if a behavioral property still holds after several model …
[HTML][HTML] ROS dependent wnt/β-catenin pathway and its regulation on defined micro-pillars—a combined in vitro and in silico study
The physico-chemical surface design of implants influences the surrounding cells.
Osteoblasts on sharp-edged micro-topographies revealed an impaired cell phenotype …
Osteoblasts on sharp-edged micro-topographies revealed an impaired cell phenotype …
[HTML][HTML] A model-driven approach for conducting simulation experiments
With the increasing complexity of simulation studies, and thus increasing complexity of
simulation experiments, there is a high demand for better support for them to be conducted …
simulation experiments, there is a high demand for better support for them to be conducted …
Context, Composition, Automation, and Communication: The C2AC Roadmap for Modeling and Simulation
Simulation has become, in many application areas, a sine qua non. Most recently, COVID-
19 has underlined the importance of simulation studies and limitations in current practices …
19 has underlined the importance of simulation studies and limitations in current practices …
Artifact-based workflows for supporting simulation studies
A Ruscheinski, T Warnke… - IEEE Transactions on …, 2019 - ieeexplore.ieee.org
Valid models are central for credible simulation studies. If those models do not exist, they
need to be developed. In fact, entire simulation studies are often aimed at developing valid …
need to be developed. In fact, entire simulation studies are often aimed at developing valid …
[HTML][HTML] Receptor/Raft ratio is a determinant for LRP6 phosphorylation and WNT/β-Catenin signaling
Microdomains or lipid rafts greatly affect the distribution of proteins and peptides in the
membrane and play a vital role in the formation and activation of receptor/protein …
membrane and play a vital role in the formation and activation of receptor/protein …
Generating fast specialized simulators for stochastic reaction networks via partial evaluation
Domain-specific modeling languages allow a clear separation between simulation model
and simulator and, thus, facilitate the development of simulation models and add to the …
and simulator and, thus, facilitate the development of simulation models and add to the …
EB-DEVS: A formal framework for modeling and simulation of emergent behavior in dynamic complex systems
D Foguelman, P Henning, A Uhrmacher… - Journal of Computational …, 2021 - Elsevier
Emergent behavior is a key feature defining a system under study as a complex system.
Simulation has been recognized as the only way to deal with the study of the emergence of …
Simulation has been recognized as the only way to deal with the study of the emergence of …
Capturing and reporting provenance information of simulation studies based on an artifact-based workflow approach
A Ruscheinski, P Wilsdorf, M Dombrowsky… - Proceedings of the …, 2019 - dl.acm.org
Provenance comprises information about how a product has been generated in a process.
Thus, provenance information about an entire simulation study would support the …
Thus, provenance information about an entire simulation study would support the …
Exploring the mechanistic and temporal regulation of LRP6 endocytosis in canonical WNT signaling
Endocytosis plays a pivotal regulatory role in canonical WNT signaling. Internalization of the
low-density lipoprotein receptor-related protein 6 (LRP6) receptor complex can either …
low-density lipoprotein receptor-related protein 6 (LRP6) receptor complex can either …