Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
Neurotoxicity of methamphetamine: Main effects and mechanisms
Methamphetamine (METH) is an illicit psychostimulant that is abused throughout the world.
METH addiction is also a major public health concern and the abuse of large doses of the …
METH addiction is also a major public health concern and the abuse of large doses of the …
In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids
Ventral midbrain dopaminergic neurons project to the striatum as well as the cortex and are
involved in movement control and reward-related cognition. In Parkinson's disease …
involved in movement control and reward-related cognition. In Parkinson's disease …
Bupropion and naltrexone in methamphetamine use disorder
MH Trivedi, R Walker, W Ling… - … England Journal of …, 2021 - Mass Medical Soc
Background The use of naltrexone plus bupropion to treat methamphetamine use disorder
has not been well studied. Methods We conducted this multisite, double-blind, two-stage …
has not been well studied. Methods We conducted this multisite, double-blind, two-stage …
Drug addiction: hyperkatifeia/negative reinforcement as a framework for medications development
Compulsive drug seeking that is associated with addiction is hypothesized to follow a
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
heuristic framework that involves three stages (binge/intoxication, withdrawal/negative affect …
Cannabis addiction and the brain: a review
Cannabis is the most commonly used substance of abuse in the United States after alcohol
and tobacco. With a recent increase in the rates of cannabis use disorder (CUD) and a …
and tobacco. With a recent increase in the rates of cannabis use disorder (CUD) and a …
Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies
BackgroundConverging lines of evidence implicate an important role for the immune system
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …
in schizophrenia. Microglia are the resident immune cells of the central nervous system and …
The effects of ketamine on dopaminergic function: meta-analysis and review of the implications for neuropsychiatric disorders
M Kokkinou, AH Ashok, OD Howes - Molecular psychiatry, 2018 - nature.com
Ketamine is a non-competitive antagonist at the N-methyl-d-aspartate receptor. It has
recently been found to have antidepressant effects and is a drug of abuse, suggesting it may …
recently been found to have antidepressant effects and is a drug of abuse, suggesting it may …
Machine learning and big data in psychiatry: toward clinical applications
Highlights•The combination of data-driven machine learning and theory-driven
computational models holds great promise for psychiatry.•Machine-learning analyses of …
computational models holds great promise for psychiatry.•Machine-learning analyses of …
The main molecular mechanisms underlying methamphetamine-induced neurotoxicity and implications for pharmacological treatment
X Yang, Y Wang, Q Li, Y Zhong, L Chen… - Frontiers in molecular …, 2018 - frontiersin.org
Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated
neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the …
neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the …