[HTML][HTML] Choosing membrane mimetics for NMR structural studies of transmembrane proteins
DE Warschawski, AA Arnold, M Beaugrand… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The native environment of membrane proteins is complex and scientists have felt the need
to simplify it to reduce the number of varying parameters. However, experimental problems …
to simplify it to reduce the number of varying parameters. However, experimental problems …
Structural and Dynamic Basis of Phospholamban and Sarcolipin Inhibition of Ca2+-ATPase
Phospholamban (PLN) and sarcolipin (SLN) are two single-pass membrane proteins that
regulate Ca2+-ATPase (SERCA), an ATP-driven pump that translocates calcium ions into …
regulate Ca2+-ATPase (SERCA), an ATP-driven pump that translocates calcium ions into …
Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach
Phospholamban (PLN) is an essential regulator of cardiac muscle contractility. The
homopentameric assembly of PLN is the reservoir for active monomers that, upon …
homopentameric assembly of PLN is the reservoir for active monomers that, upon …
α-Helical transmembrane peptides: a “divide and conquer” approach to membrane proteins
N Bordag, S Keller - Chemistry and physics of lipids, 2010 - Elsevier
α-Helical membrane proteins fulfill many vital roles in all living cells and constitute the
majority of drug targets. However, their relevance is in no way paralleled by our current …
majority of drug targets. However, their relevance is in no way paralleled by our current …
Structural dynamics and topology of phospholamban in oriented lipid bilayers using multidimensional solid-state NMR
NJ Traaseth, JJ Buffy, J Zamoon, G Veglia - Biochemistry, 2006 - ACS Publications
Phospholamban (PLN), a single-pass membrane protein, regulates heart muscle contraction
and relaxation by reversible inhibition of the sarco (endo) plasmic reticulum Ca-ATPase …
and relaxation by reversible inhibition of the sarco (endo) plasmic reticulum Ca-ATPase …
Phospholamban and Its Phosphorylated Form Interact Differently with Lipid Bilayers: A 31P, 2H, and 13C Solid-State NMR Spectroscopic Study
S Abu-Baker, GA Lorigan - Biochemistry, 2006 - ACS Publications
Phospholamban (PLB) is a 52-amino acid integral membrane protein that helps to regulate
the flow of Ca2+ ions in cardiac muscle cells. Recent structural studies on the PLB pentamer …
the flow of Ca2+ ions in cardiac muscle cells. Recent structural studies on the PLB pentamer …
Solid-State NMR Study to Probe the Effects of Divalent Metal Ions (Ca2+ and Mg2+) on the Magnetic Alignment of Polymer-Based Lipid Nanodiscs
Divalent cations, especially Ca2+ and Mg2+, play a vital role in the function of biomolecules
and making them important to be constituents in samples for in vitro biophysical and …
and making them important to be constituents in samples for in vitro biophysical and …
A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles
JE McCaffrey, ZM James, B Svensson… - Journal of magnetic …, 2016 - Elsevier
We have applied a bifunctional spin label and EPR spectroscopy to determine membrane
protein structural topology in magnetically-aligned bicelles, using monomeric …
protein structural topology in magnetically-aligned bicelles, using monomeric …
[HTML][HTML] Probing the helical tilt and dynamic properties of membrane-bound phospholamban in magnetically aligned bicelles using electron paramagnetic resonance …
Wild-type phospholamban (WT-PLB), a Ca2+-ATPase (SERCA) regulator in the
sarcoplasmic reticulum membrane, was studied using TOAC nitroxide spin labeling …
sarcoplasmic reticulum membrane, was studied using TOAC nitroxide spin labeling …
[HTML][HTML] Solid-state 2H and 15N NMR studies of side-chain and backbone dynamics of phospholamban in lipid bilayers: Investigation of the N27A mutation
S Chu, AT Coey, GA Lorigan - Biochimica et Biophysica Acta (BBA) …, 2010 - Elsevier
Phospholamban (PLB) is an integral membrane protein regulating Ca2+ transport through
inhibitory interaction with sarco (endo) plasmic reticulum calcium ATPase (SERCA). The …
inhibitory interaction with sarco (endo) plasmic reticulum calcium ATPase (SERCA). The …