Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Platelets are the “guardians” of the blood circulatory system. At sites of vessel injury, they
ensure hemostasis and promote immunity and vessel repair. However, their uncontrolled …

Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10
cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves …

Asthma is defined by airway inflammation and hyperresponsiveness, and contributes to
morbidity and mortality worldwide. Although bronchodilation is a cornerstone of treatment …

Campomanesia adamantium is a medicinal plant of the Brazilian Cerrado. Different parts of
its fruits are used in popular medicine to treat gastrointestinal disorders, rheumatism, urinary …

Lower urinary tract symptoms (LUTS), comprising storage (such as urinary incontinence and
urinary frequency), voiding, and postmicturition symptoms, are highly prevalent conditions …

In this study, we have identified cystathionine (CTH), a sulfur containing metabolite, to be
selectively enriched in human breast cancer (HBC) tissues (∼ 50–100 pmoles/mg protein) …

MRP4 is an ABC membrane transporter involved in clinical outcomes as it is located in many
tissues that manages the transport and the elimination of many drugs. This review explores …

Diabetes is associated with an increased mortality risk due to cardiovascular complications.
Hyperglycemia-induced oxidative stress underlies these complications, leading to an …

Background and Purpose Nitric oxide (NO) activates soluble guanylyl cyclase (sGC) for
cGMP production, but in disease, sGC becomes insensitive towards NO activation. What …