An insight into medicinal attributes of dithiocarbamates: Bird's eye view
Dithiocarbamates are considered as an important motif owing to its extensive biological
applications in medicinal chemistry. The synthesis of this framework can easily be achieved …
applications in medicinal chemistry. The synthesis of this framework can easily be achieved …
Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-κβ pathway
Aim: To fabricate and evaluate curcumin-loaded transfersomes (Cur-TF) for the targeted
delivery and enhanced therapeutic efficacy of curcumin for the treatment of rheumatoid …
delivery and enhanced therapeutic efficacy of curcumin for the treatment of rheumatoid …
Preparation, characterization, and pharmacological application of oral Honokiol-loaded solid lipid nanoparticles for diabetic neuropathy
Honokiol is a phytochemical component with a variety of pharmacological properties.
However, the major limitation of Honokiol is its poor solubility and low oral bioavailability. In …
However, the major limitation of Honokiol is its poor solubility and low oral bioavailability. In …
[HTML][HTML] Suppression of TRPV1/TRPM8/P2Y nociceptors by withametelin via downregulating MAPK signaling in mouse model of vincristine-induced neuropathic pain
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …
Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy
This study aimed to investigate the anti-neuropathic pain activity and its underlying
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …
molecular mechanism of Ajugarin-I (Aju-I) in a rat model of diabetic neuropathic pain. The …
Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2/HO-1 and TLR4/NF-κB signaling
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central
nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed …
nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed …
Alleviation of memory deficit by bergenin via the regulation of reelin and Nrf-2/NF-κB pathway in transgenic mouse model
The present study aims to determine the neuroprotective effect of Bergenin against spatial
memory deficit associated with neurodegeneration. Preliminarily, the protective effect of …
memory deficit associated with neurodegeneration. Preliminarily, the protective effect of …
Aerodynamic properties and in silico deposition of isoniazid loaded chitosan/thiolated chitosan and hyaluronic acid hybrid nanoplex DPIs as a potential TB treatment
Existing therapies yield low drug encapsulation or accumulation in the lungs, hence the site-
specific drug delivery remains the challenge for tuberculosis. Lately, dry powder inhalers …
specific drug delivery remains the challenge for tuberculosis. Lately, dry powder inhalers …
Attenuation of nociceptive and paclitaxel-induced neuropathic pain by targeting inflammatory, CGRP and substance P signaling using 3-Hydroxyflavone
Paclitaxel is an anti-microtubule agent, most widely used chemotherapeutic agent for the
treatment of malignant solid tumors. However, it is associated with some severe side effects …
treatment of malignant solid tumors. However, it is associated with some severe side effects …
Matrine alleviates neurobehavioral alterations via modulation of JNK-mediated caspase-3 and BDNF/VEGF signaling in a mouse model of burn injury
Abstract Rationale The c-Jun N-terminal kinase (JNK) pathway and neurotrophic factor
dysregulation play a critical role in the pathogenesis of neurobehavioral disorders (anxiety …
dysregulation play a critical role in the pathogenesis of neurobehavioral disorders (anxiety …