Cilia, organelles that move to execute functions like fertilization and signal to execute
functions like photoreception and embryonic patterning, are composed of a core of nine-fold …

Congenital cataracts, the most common cause of visual impairment and blindness in
children worldwide, have diverse etiologies. According to statistics analysis, about one …

Phosphoinositides (PIs) are phospholipids derived from phosphatidylinositol. PIs are
regulated via reversible phosphorylation, which is directed by the opposing actions of PI …

Bridge the gap between ophthalmology and pathology with the 8th Edition of this
comprehensive, easy-to-understand reference from Drs. Myron Yanoff and Joseph W …

Primary cilia are sensory organelles on many postmitotic cells. The ciliary membrane is
continuous with the plasma membrane but differs in its phospholipid composition with …

Primary cilia are immotile organelles known for their roles in development and cell signaling.
Defects in primary cilia result in a range of disorders named ciliopathies. Because this …

Over-activation of the PI3K/Akt/mTOR network is a well-known pathogenic event that leads
to hyper-proliferation. Pharmacological targeting of this pathway has been developed for the …

The primary cilium has gone from being a vestigial organelle to a crucial signaling hub of
growing interest given the association between a group of human disorders, collectively …

Primary cilia are solitary signalling organelles projecting from the surface of most cell types.
Although the ciliary membrane is continuous with the plasma membrane it exhibits a unique …

PIK3C2A is a class II member of the phosphoinositide 3-kinase (PI3K) family that catalyzes
the phosphorylation of phosphatidylinositol (PI) into PI (3) P and the phosphorylation of PI …