Microphysiology systems (MPS), also called organs-on-chips and tissue chips, are
miniaturized functional units of organs constructed with multiple cell types under a variety of …

Fluorogenic biosensors are essential tools widely used in biomedicine, chemical biology,
environmental protection and food safety. Fluorescence resonance energy transfer (FRET) …

Cellular function is controlled through intricate networks of signals, which lead to the myriad
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive
diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen …

We describe a novel molecular strategy for engendering a strong light-up signal in
fluorescence tagging of the genetically encoded HaloTag protein domain. We designed a …

Metabolic syndrome is a complex disease that involves multiple organ systems including a
critical role for the liver. Non-alcoholic fatty liver disease (NAFLD) is a key component of the …

Two technologies that have emerged in the last decade offer a new paradigm for modern
pharmacology, as well as drug discovery and development. Quantitative systems …

Autophagy is an essential cellular process of self-degradation for dysfunctional or
unnecessary cytosolic constituents and organelles. Dysregulation of autophagy is thus …

Green fluorescent protein (GFP) is a globular protein used as biosensor and biomarker in
medical and industrial fields. However, due to the expensive production costs of expressing …

Bacteria lies at the root of many infectious and non–infectious diseases. To control and
prevent those diseases, there is an urgent need for the rapid and affordable microbial …