The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …

The activity‐dependent fusion, retrieval and recycling of synaptic vesicles is essential for the
maintenance of neurotransmission. Until relatively recently it was believed that most …

Heterozygous mutations in proline-rich transmembrane protein 2 (PRRT2) underlie a group
of paroxysmal disorders, including epilepsy, kinesigenic dyskinesia, and migraine. Most of …

Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …

Mutations in Leucine-Rich Repeat Kinase-2 (LRRK2) result in familial Parkinson's disease
and the G2019S mutation alone accounts for up to 30% in some ethnicities. Despite this, the …

Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …

Neuronal presynaptic terminals contain hundreds of neurotransmitter‐filled synaptic vesicles
(SVs). The morphologically uniform SVs differ in their release competence segregating into …

Abstract Mutations in PRoline-Rich Transmembrane protein 2 (PRRT2) underlie a group of
paroxysmal disorders including epilepsy, kinesigenic dyskinesia and migraine. Most of the …

Brain-derived neurotrophic factor (BDNF) signaling via TrkB crucially regulates synaptic
plasticity in the brain. Although BDNF is abundant at hippocampal mossy fiber (MF) …

Synapsin I (SynI) is a synaptic vesicle (SV) phosphoprotein playing multiple roles in synaptic
transmission and plasticity by differentially affecting crucial steps of SV trafficking in …