Regulation of hippocampal synaptic plasticity by BDNF
G Leal, PM Afonso, IL Salazar, CB Duarte - Brain research, 2015 - Elsevier
The neurotrophin brain-derived neurotrophic factor (BDNF) has emerged as a major
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …
regulator of activity-dependent plasticity at excitatory synapses in the mammalian central …
Presynaptic dysfunction in neurodevelopmental disorders: Insights from the synaptic vesicle life cycle
K Bonnycastle, EC Davenport… - Journal of …, 2021 - Wiley Online Library
The activity‐dependent fusion, retrieval and recycling of synaptic vesicles is essential for the
maintenance of neurotransmission. Until relatively recently it was believed that most …
maintenance of neurotransmission. Until relatively recently it was believed that most …
PRRT2 is a key component of the Ca2+-dependent neurotransmitter release machinery
Heterozygous mutations in proline-rich transmembrane protein 2 (PRRT2) underlie a group
of paroxysmal disorders, including epilepsy, kinesigenic dyskinesia, and migraine. Most of …
of paroxysmal disorders, including epilepsy, kinesigenic dyskinesia, and migraine. Most of …
Regulation of the hippocampal translatome by Apoer2-ICD release
CR Wasser, GC Werthmann, EM Hall… - Molecular …, 2023 - Springer
Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer's disease
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …
(AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal …
Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice
DA Beccano-Kelly, N Kuhlmann, I Tatarnikov… - Frontiers in cellular …, 2014 - frontiersin.org
Mutations in Leucine-Rich Repeat Kinase-2 (LRRK2) result in familial Parkinson's disease
and the G2019S mutation alone accounts for up to 30% in some ethnicities. Despite this, the …
and the G2019S mutation alone accounts for up to 30% in some ethnicities. Despite this, the …
An updated reappraisal of synapsins: structure, function and role in neurological and psychiatric disorders
F Longhena, G Faustini, V Brembati, M Pizzi… - Neuroscience & …, 2021 - Elsevier
Synapsins (Syns) are phosphoproteins strongly involved in neuronal development and
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …
neurotransmitter release. Three distinct genes SYN1, SYN2 and SYN3, with elevated …
Bassoon controls synaptic vesicle release via regulation of presynaptic phosphorylation and cAMP
C Montenegro‐Venegas, D Guhathakurta… - EMBO …, 2022 - embopress.org
Neuronal presynaptic terminals contain hundreds of neurotransmitter‐filled synaptic vesicles
(SVs). The morphologically uniform SVs differ in their release competence segregating into …
(SVs). The morphologically uniform SVs differ in their release competence segregating into …
Constitutive inactivation of the PRRT2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons
P Valente, A Romei, M Fadda, B Sterlini… - Cerebral …, 2019 - academic.oup.com
Abstract Mutations in PRoline-Rich Transmembrane protein 2 (PRRT2) underlie a group of
paroxysmal disorders including epilepsy, kinesigenic dyskinesia and migraine. Most of the …
paroxysmal disorders including epilepsy, kinesigenic dyskinesia and migraine. Most of the …
Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus
S Schildt, T Endres, V Lessmann, E Edelmann - Neuropharmacology, 2013 - Elsevier
Brain-derived neurotrophic factor (BDNF) signaling via TrkB crucially regulates synaptic
plasticity in the brain. Although BDNF is abundant at hippocampal mossy fiber (MF) …
plasticity in the brain. Although BDNF is abundant at hippocampal mossy fiber (MF) …
Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity
Synapsin I (SynI) is a synaptic vesicle (SV) phosphoprotein playing multiple roles in synaptic
transmission and plasticity by differentially affecting crucial steps of SV trafficking in …
transmission and plasticity by differentially affecting crucial steps of SV trafficking in …