Structure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)

AIM Salah Ud-Din, A Tikhomirova… - International journal of …, 2016 - mdpi.com
General control non-repressible 5 (GCN5)-related N-acetyltransferases (GNAT) catalyze the
transfer of an acyl moiety from acyl coenzyme A (acyl-CoA) to a diverse group of substrates …

Blockade of NMT1 enzymatic activity inhibits N-myristoylation of VILIP3 protein and suppresses liver cancer progression

XP Tan, Y He, J Yang, X Wei, YL Fan… - … and Targeted Therapy, 2023 - nature.com
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Identification
of the underlying mechanism of HCC progression and exploration of new therapeutic drugs …

ERα36–Another piece of the estrogen puzzle

K Sołtysik, P Czekaj - European Journal of Cell Biology, 2015 - Elsevier
Although the nuclear action of estrogen receptors (ER) is a well-known fact, evidence
supporting membrane estrogen receptors is steadily accumulating. New ER variants of …

Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition

E Beauchamp, JM Gamma, CR Cromwell… - Journal of Translational …, 2024 - Springer
Background In humans, two ubiquitously expressed N-myristoyltransferases, NMT1 and
NMT2, catalyze myristate transfer to proteins to facilitate membrane targeting and signaling …

Association of Gene Expression and Tremor Network Structure

T Welton, G Chew, AS Mai, JH Ng, LL Chan… - Movement …, 2024 - Wiley Online Library
Background Transcriptomic changes in the essential tremor (ET)–associated cerebello‐
thalamo‐cortical “tremor network” and their association to brain structure have not been …

Src nuclear localization and its prognostic relevance in human osteosarcoma

E Urciuoli, I Coletta, E Rizzuto, R De Vito… - Journal of Cellular …, 2018 - Wiley Online Library
Osteosarcoma is the most common malignant bone tumor in children and young adults. The
identification of proteins which exhibit different subcellular localization in low‐versus high …

[HTML][HTML] Ternary structure of Plasmodium vivax N-myristoyltransferase with myristoyl-CoA and inhibitor IMP-0001173

C Bolling, A Mendez, S Taylor, S Makumire… - Structural Biology and …, 2024 - journals.iucr.org
Plasmodium vivax is a major cause of malaria, which poses an increased health burden on
approximately one third of the world's population due to climate change. Primaquine, the …

NMT1 enhances the stemness of NSCLC cells by activating the PI3K/AKT pathway

W Zou, X Zhang, Y Wang, L Yan, X Wu, R Yang, Y Li… - Pharmacology, 2022 - karger.com
Introduction: Abundant studies have disclosed that proteins can function as pivotal tumor
promoters or suppressors in cancers' progression. This work was planned to investigate the …

Structure of Plasmodium vivax N-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

A Mendez, C Bolling, S Taylor, S Makumire… - Structural Biology and …, 2025 - journals.iucr.org
Plasmodium vivax, a significant contributor to global malaria cases, poses an escalating
health burden on a substantial portion of the world's population. The increasing spread of P …

Diseño racional, síntesis y caracterización de híbridos quiméricos de heterociclos nitrogenados y azufrados como potenciales agentes antifúngicos

GR Páez Ramos - repositorio.unal.edu.co
Las altas tasas de morbilidad y mortalidad causadas por infecciones fúngicas están
intrínsecamente relacionadas con el desarrollo limitado de antimicóticos y la alta toxicidad …