Bilirubin-Induced Neurologic Damage — Mechanisms and Management Approaches | New
England Journal of Medicine Skip to main content The New England Journal of Medicine …

Abstract von Willebrand Factor (vWF) was found to mediate platelet influx during the early
phase of liver regeneration in mice. Furthermore, increased vWF‐antigen (vWF‐Ag) levels …

Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …

Unconjugated bilirubin (UCB) is responsible for neonatal jaundice and high level of free
bilirubin (Bf) can lead to kernicterus. Previous studies suggest that oxidative stress is a …

Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades,
yet the molecular mechanisms at the core of this damage remain largely unknown …

Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.
However, at high concentrations, it produces severe neurological damage and death …

Objective Jaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the
tissue and is indicative of potential toxicity to the brain. Since its very first description more …

Research on the mechanisms of bilirubin-induced neurological dysfunction focuses mainly
on neuronal death, astrocyte-mediated events and microglia activation. Although myelin …

Approximately 80% of newborns worldwide have some degree of hyperbilirubinemia and
visible jaundice. 1 Severe cases of hyperbilirubinemia can progress to kernicterus and lead …

Cisplatin is used widely for treatment of a variety of cancer diseases. Recently, however, the
use of cisplatin is restricted because of its adverse effects such as hepatotoxicity. There is no …