The ends of eukaryotic chromosomes have the potential to be mistaken for damaged or
broken DNA and must therefore be protected from cellular DNA damage response …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism …

Double-strand breaks (DSBs) are deleterious DNA lesions and if left unrepaired result in
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …

The replication of the ends of linear chromosomes, or telomeres, poses unique problems,
which must be solved to maintain genome integrity and to allow cell division to occur. Here …

Chromosome end protection is essential to protect genome integrity. Telomeres, tracts of
repetitive DNA sequence and associated proteins located at the chromosomal terminus …

Abstract Cdc13, Stn1 and Ten1 are essential yeast proteins that both protect chromosome
termini from unregulated resection and regulate telomere length. Cdc13, which localizes to …

DNA double-strand breaks (DSBs) are among the most deleterious type of DNA lesions
threatening genome integrity. Homologous recombination (HR) and non-homologous end …

The ends of linear eukaryotic chromosomes are protected by telomeres, which serve to
ensure proper chromosome replication and to prevent spurious recombination at …