Glioma targeted therapy: insight into future of molecular approaches

K Yang, Z Wu, H Zhang, N Zhang, W Wu, Z Wang… - Molecular Cancer, 2022 - Springer
Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?

SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Targeting CD47 for cancer immunotherapy

Z Jiang, H Sun, J Yu, W Tian, Y Song - Journal of Hematology & Oncology, 2021 - Springer
Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors
(ST) and hematological malignancies. We summarized the CD47-related clinical research …

Phagocytosis checkpoints as new targets for cancer immunotherapy

M Feng, W Jiang, BYS Kim, CC Zhang, YX Fu… - Nature Reviews …, 2019 - nature.com
Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

The CD47-SIRPα immune checkpoint

MEW Logtenberg, FA Scheeren, TN Schumacher - Immunity, 2020 - cell.com
The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted
through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein …

Advances in drug delivery systems based on red blood cells and their membrane-derived nanoparticles

PHD Nguyen, MK Jayasinghe, AH Le, B Peng… - ACS nano, 2023 - ACS Publications
Red blood cells (RBCs) and RBC membrane-derived nanoparticles have been historically
developed as bioinspired drug delivery systems to combat the issues of premature …

Targeting macrophages: therapeutic approaches in cancer

L Cassetta, JW Pollard - Nature reviews Drug discovery, 2018 - nature.com
Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

CA Butler, AS Popescu, EJA Kitchener… - Journal of …, 2021 - Wiley Online Library
There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …