Making sense of cancer genomic data
L Chin, WC Hahn, G Getz, M Meyerson - Genes & development, 2011 - genesdev.cshlp.org
High-throughput tools for nucleic acid characterization now provide the means to conduct
comprehensive analyses of all somatic alterations in the cancer genomes. Both large-scale …
comprehensive analyses of all somatic alterations in the cancer genomes. Both large-scale …
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
EC De Bruin, N McGranahan, R Mitter, M Salm… - Science, 2014 - science.org
Spatial and temporal dissection of the genomic changes occurring during the evolution of
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal …
human non–small cell lung cancer (NSCLC) may help elucidate the basis for its dismal …
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
Malignant peripheral nerve sheath tumors (MPNSTs) represent a group of highly aggressive
soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type …
soft-tissue sarcomas that may occur sporadically, in association with neurofibromatosis type …
[HTML][HTML] Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations
Background & Aims Biliary tract cancers (BTCs) are clinically and pathologically
heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer …
heterogeneous and respond poorly to treatment. Genomic profiling can offer a clearer …
Exome sequencing identifies distinct mutational patterns in liver fluke–related and non-infection-related bile duct cancers
The impact of different carcinogenic exposures on the specific patterns of somatic mutation
in human tumors remains unclear. To address this issue, we profiled 209 …
in human tumors remains unclear. To address this issue, we profiled 209 …
Telomeric allelic imbalance indicates defective DNA repair and sensitivity to DNA-damaging agents
DNA repair competency is one determinant of sensitivity to certain chemotherapy drugs,
such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome …
such as cisplatin. Cancer cells with intact DNA repair can avoid the accumulation of genome …
Exome sequencing of liver fluke–associated cholangiocarcinoma
CK Ong, C Subimerb, C Pairojkul, S Wongkham… - Nature …, 2012 - nature.com
Opisthorchis viverrini–related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major
public health concern in areas endemic for this parasite. We report here whole-exome …
public health concern in areas endemic for this parasite. We report here whole-exome …
Pan-cancer analysis of genomic scar signatures associated with homologous recombination deficiency suggests novel indications for existing cancer drugs
Background Ovarian and triple-negative breast cancers with BRCA1 or BRCA2 loss are
highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and …
highly sensitive to treatment with PARP inhibitors and platinum-based cytotoxic agents and …
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast …
Loss of heterozygosity (LOH) and copy number alteration (CNA) feature prominently in the
somatic genomic landscape of tumors. As such, karyotypic aberrations in cancer genomes …
somatic genomic landscape of tumors. As such, karyotypic aberrations in cancer genomes …
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair
Defining mechanisms that generate intratumour heterogeneity and branched evolution may
inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su …
inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su …