Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Severe or life threatening infections are common among patients in the intensive care unit
(ICU). Most infections in the ICU are bacterial or fungal in origin and require antimicrobial …

Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Abstract Scope The Dutch Working Party on Antibiotic Policy constituted a multidisciplinary
expert committee to provide evidence-based recommendation for the use of antibacterial …

Acute-on-chronic liver failure (ACLF), which was described relatively recently (2013), is a
severe form of acutely decompensated cirrhosis characterised by the existence of organ …

Invasive candidiasis is the most common critical care-associated fungal infection with a
crude mortality of~ 40–55%. Important factors contributing to risk of invasive candidiasis in …

Background: Recent studies have identified the combination of vancomycin with piperacillin-
tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort …

Antibiotics are recognized widely for their benefits when used appropriately. However, they
are often used inappropriately despite the importance of responsible use within good clinical …

Objectives Stenotrophomonas maltophilia (S. maltophilia), an opportunistic pathogen,
causes infection in patients undergoing immunosuppressive therapy, mechanical …

Antimicrobial de-escalation (ADE) is defined as the discontinuation of one or more
components of combination empirical therapy, and/or the change from a broad-spectrum to …