DNA double-strand break (DSB) signalling and repair is crucial to preserve genomic
integrity and maintain cellular homeostasis. p53-binding protein 1 (53BP1) is an important …

This review describes the structure of telomeres, the protective DNA-protein complexes at
eukaryotic chromosomal ends, and several molecular mechanisms involved in telomere …

Maintenance of a minimal telomere length is essential to prevent cellular senescence. When
critically short telomeres arise in the absence of telomerase, they can be repaired by …

The appropriate execution of DNA double-strand break (DSB) repair is critical for genome
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …

Normal human cells undergo a finite number of cell divisions and ultimately enter a
nondividing state called replicative senescence. It has been proposed that telomere …

Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles,
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

We developed the Yeast Gene Order Browser (YGOB; http://wolfe. gen. tcd. ie/ygob) to
facilitate visual comparisons and computational analysis of synteny relationships in yeasts …

Telomeres are the protective DNA–protein complexes found at the ends of eukaryotic
chromosomes. Telomeric DNA consists of tandem repeats of a simple, often G–rich …