Exosomes: key players in cancer and potential therapeutic strategy

J Dai, Y Su, S Zhong, L Cong, B Liu, J Yang… - Signal transduction and …, 2020 - nature.com
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

RNA delivery by extracellular vesicles in mammalian cells and its applications

K O'Brien, K Breyne, S Ughetto, LC Laurent… - … reviews Molecular cell …, 2020 - nature.com
The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

CircRNAs: role in human diseases and potential use as biomarkers

L Verduci, E Tarcitano, S Strano, Y Yarden… - Cell death & …, 2021 - nature.com
Circular RNAs (circRNAs) are a class of endogenous RNAs characterized by a covalent
loop structure. In comparison to other types of RNAs, the abundance of circRNAs is relatively …

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

X Zhang, Y Xu, L Ma, K Yu, Y Niu, X Xu… - Cancer …, 2022 - Wiley Online Library
Background Resistance to ferroptosis, a regulated cell death caused by iron‐dependent
excessive accumulation of lipid peroxides, has recently been linked to lung adenocarcinoma …

Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis

H Xie, J Yao, Y Wang, B Ni - Drug delivery, 2022 - Taylor & Francis
Abstract Background Circular RNAs (circRNAs) play important regulatory roles in multiple
human malignancies, including non-small cell lung cancer (NSCLC). Here, we explored the …

Plant noncoding RNAs: hidden players in development and stress responses

Y Yu, Y Zhang, X Chen, Y Chen - Annual review of cell and …, 2019 - annualreviews.org
A large and significant portion of eukaryotic transcriptomes consists of noncoding RNAs
(ncRNAs) that have minimal or no protein-coding capacity but are functional. Diverse …

Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression

W Chen, Y Quan, S Fan, H Wang, J Liang, L Huang… - Cancer letters, 2020 - Elsevier
Extracellular communication in the tumor microenvironment is critical. Results of qRT-PCR
show that circ-0051443 is significantly lower in the plasma exosomes and tissues from …

[HTML][HTML] Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis

H Yang, H Zhang, Y Yang, X Wang, T Deng, R Liu… - Theranostics, 2020 - ncbi.nlm.nih.gov
Hypoxia is one of the important properties of solid tumor. However, oxygen supply within
tumors is generally heterogeneous according to the distance from the nearest blood vessel …

A novel protein encoded by exosomal CircATG4B induces oxaliplatin resistance in colorectal cancer by promoting autophagy

Z Pan, J Zheng, J Zhang, J Lin, J Lai, Z Lyu… - Advanced …, 2022 - Wiley Online Library
Oxaliplatin is commonly used in chemotherapeutic regimens for colorectal cancer (CRC)
after surgical resection. However, acquired chemoresistance seriously affects the curative …

Comprehensive proteomic analysis of exosomes derived from human bone marrow, adipose tissue, and umbilical cord mesenchymal stem cells

Z Wang, Z He, S Liang, Q Yang, P Cheng… - Stem Cell Research & …, 2020 - Springer
Background Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive
application prospects over the years. Despite performing similar functions, exosomes from …