I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between
hepatic glucose production and glucose utilization by the major insulin-dependent tissues …

Insulin receptors in the central nervous system: Localization, signalling mechanisms and
functional aspects - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & …

The X-ray crystal structure of the tyrosine kinase domain of the human insulin receptor has
been determined by multiwavelength anomalous diffraction phasing and refined to 2.1 Å …

The person who passes urine which is exceedingly sweet, cool, slightly viscid, turbid, and
resembling the juices of the sugarcane… suffers from glycosuria.… There are two types of …

Insulin receptor signaling has been postulated to play a role in synaptic plasticity; however,
the function of the insulin receptor in CNS is not clear. To test whether insulin receptor …

Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a
screen for small molecules that activate the human insulin receptor tyrosine kinase, a …

Insulin resistance is defined as a clinical state in which a normal or elevated insulin level
produces an attenuated biologic response. Specifically, the biologic response most studied …

Characterized as a peripheral metabolic disorder and a degenerative disease of the central
nervous system respectively, it is now widely recognized that type 2 diabetes mellitus …

To determine whether the impaired insulin-stimulated glucose uptake in obese individuals is
associated with altered insulin receptor signaling, we measured both glucose uptake and …

Cloning of the insulin receptor cDNA has earlier revealed the existence of two alternative
forms of the receptor differing by the presence or absence of 12 amino acids near the C …