The uniqueness of albumin as a carrier in nanodrug delivery

A Spada, J Emami, JA Tuszynski… - Molecular …, 2021 - ACS Publications
Albumin is an appealing carrier in nanomedicine because of its unique features. First, it is
the most abundant protein in plasma, endowing high biocompatibility, biodegradability …

[HTML][HTML] Protein-based nanoparticles as drug delivery systems

S Hong, DW Choi, HN Kim, CG Park, W Lee, HH Park - Pharmaceutics, 2020 - mdpi.com
Nanoparticles have been extensively used as carriers for the delivery of chemicals and
biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural …

Albumin-based drug delivery: harnessing nature to cure disease

MT Larsen, M Kuhlmann, ML Hvam… - Molecular and cellular …, 2016 - Springer
The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic
levels, however, challenges such as rapid renal clearance, degradation or non-specific …

Human serum albumin: from bench to bedside

G Fanali, A Di Masi, V Trezza, M Marino… - Molecular aspects of …, 2012 - Elsevier
Human serum albumin (HSA), the most abundant protein in plasma, is a monomeric multi-
domain macromolecule, representing the main determinant of plasma oncotic pressure and …

Albumin-based nanoparticles as potential controlled release drug delivery systems

AO Elzoghby, WM Samy, NA Elgindy - Journal of controlled release, 2012 - Elsevier
Albumin, a versatile protein carrier for drug delivery, has been shown to be nontoxic, non-
immunogenic, biocompatible and biodegradable. Therefore, it is ideal material to fabricate …

Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles

F Kratz - Journal of controlled release, 2008 - Elsevier
Albumin is playing an increasing role as a drug carrier in the clinical setting. Principally,
three drug delivery technologies can be distinguished: coupling of low-molecular weight …

Interactive association of drugs binding to human serum albumin

F Yang, Y Zhang, H Liang - International journal of molecular sciences, 2014 - mdpi.com
Human serum albumin (HSA) is an abundant plasma protein, which attracts great interest in
the pharmaceutical industry since it can bind a remarkable variety of drugs impacting their …

Signaling mechanisms regulating endothelial permeability

D Mehta, AB Malik - Physiological reviews, 2006 - journals.physiology.org
The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

The extraordinary ligand binding properties of human serum albumin

M Fasano, S Curry, E Terreno, M Galliano, G Fanali… - IUBMB …, 2005 - Wiley Online Library
Human serum albumin (HSA), the most prominent protein in plasma, binds different classes
of ligands at multiple sites. HSA provides a depot for many compounds, affects …

[PDF][PDF] Albumin: biochemical properties and therapeutic potential

GJ Quinlan, GS Martin, TW Evans - Hepatology, 2005 - Wiley Online Library
Human serum albumin (HSA) is an abundant mul-tifunctional non-glycosylated, negatively
charged plasma protein, with ascribed ligand-binding and transport properties, antioxidant …