Nucleotide excision repair (NER) is the main pathway used by mammals to remove bulky
DNA lesions such as those formed by UV light, environmental mutagens, and some cancer …

The early notion that cancer is caused by mutations in genes critical for the control of cell
growth implied that genome stability is important for preventing oncogenesis. During the …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

Summary The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of
cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects …

In unstressed cells, the tumor suppressor protein p53 is present in a latent state and is
maintained at low levels through targeted degradation. A variety of genotoxic stresses …

Over the past few years, media have popularized the story of the “children of the moon” who
must remain in the dark and avoid exposure to sunlight. 1r3 These children suffer from a rare …

Here, we describe the assembly of the nucleotide excision repair (NER) complex in normal
and repair-deficient (xeroderma pigmentosum) human cells, employing a novel technique of …

Ultraviolet (UV) light-induced pyrimidine photodimers are repaired by the nucleotide
excision repair pathway. Photolesions have biophysical parameters closely resembling …

The xeroderma pigmentosum group C (XPC) protein complex plays a key role in
recognizing DNA damage throughout the genome for mammalian nucleotide excision repair …

Numerous agents of endogenous and exogenous origin damage DNA in our genome.
There are several DNA‐repair pathways that recognize lesions in DNA and remove them …