A keratin code defines the textile nature of epithelial tissue architecture

J Di Russo, TM Magin, RE Leube - Current Opinion in Cell Biology, 2023 - Elsevier
We suggest that the human body can be viewed as of textile nature whose fabric consists of
interconnected fiber systems. These fiber systems form highly dynamic scaffolds, which …

A kaleidoscope of keratin gene expression and the mosaic of its regulatory mechanisms

EP Kalabusheva, AS Shtompel, AL Rippa… - International Journal of …, 2023 - mdpi.com
Keratins are a family of intermediate filament-forming proteins highly specific to epithelial
cells. A combination of expressed keratin genes is a defining property of the epithelium …

Keratin 15 protects against cigarette smoke-induced epithelial mesenchymal transformation by MMP-9

W Zhu, L Han, Y Wu, L Tong, L He, Q Wang, Y Yan… - Respiratory …, 2023 - Springer
Background Chronic obstructive pulmonary disease (COPD), a chronic inflammatory lung
disease, is a leading cause of morbidity and mortality worldwide. Prolonged cigarette …

Off-label use of Baricitinib improves moderate and severe atopic dermatitis in China through inhibiting MAPK and PI3K/Akt/mTOR pathway via targeting JAK-STAT …

S Chen, C Li, Z Tu, T Cai, X Zhang, L Wang… - Frontiers in …, 2024 - frontiersin.org
As an inflammatory disease with a disrupted immune system, cytokine disorders in atopic
dermatitis (AD) are closely related to the abnormal activation of JAK-STAT signal pathway …

Knockout of STE20-type kinase TAOK3 does not attenuate diet-induced NAFLD development in mice

Y Xia, E Andersson, M Caputo, E Cansby, F Sedda… - Molecular …, 2023 - Springer
Objective Non-alcoholic fatty liver disease (NAFLD), the primary hepatic consequence of
obesity, is affecting about 25% of the global adult population. The aim of this study was to …

Synergistic delivery of hADSC-Exos and antioxidants has inhibitory effects on UVB-induced skin photoaging

Y Fu, J Xie, W Zhang, X Zhang, XM Zhang, M Xu… - Heliyon, 2024 - cell.com
Ultraviolet B (UVB) light exposure accelerates skin photoaging. Human adipose-derived
stem cell exosomes (hADSC-Exos) and some antioxidants may have anti-photoaging …

An anoikis-based gene signature for predicting prognosis in malignant pleural mesothelioma and revealing immune infiltration

J Shi, B Peng, X Zhou, C Wang, R Xu, T Lu… - Journal of Cancer …, 2023 - Springer
Introduction Malignant pleural mesothelioma (MPM) is an aggressive, treatment-resistant
tumor. Anoikis is a particular type of programmed apoptosis brought on by the separation of …

Rebalancing Viral and Immune Damage versus Tissue Repair Prevents Death from Lethal Influenza Infection

H Ichise, E Speranza, F La Russa, TZ Veres, CJ Chu… - bioRxiv, 2024 - biorxiv.org
Maintaining tissue function while eliminating infected cells is fundamental to host defense.
Innate inflammatory damage contributes to lethal influenza and COVID-19, yet other than …

Development and characterization of ferret ex vivo tracheal injury and cell engraftment model

V Ievlev, AC Pai, DS Dillon Jr, S Kuhl, TJ Lynch… - Frontiers in …, 2023 - frontiersin.org
The field of airway biology research relies primarily on in vitro and in vivo models of disease
and injury. The use of ex vivo models to study airway injury and cell-based therapies …

Persistent alveolar bronchiolization, interstitial fibrosis and impaired lung function post-exercise are features of long-COVID in SARS-CoV-2-Delta variant infected …

W Baumgärtner, L Heydemann, M Ciurkiewicz, T Störk… - 2024 - researchsquare.com
Long-term consequences of SARS-CoV-2 infection affect the life quality of millions of people
and pose a heavy burden on the public health sector. The underlying causes …