An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

Advances in single-cell RNA sequencing (scRNA-seq) technologies in the past 10 years
have had a transformative effect on biomedical research, enabling the profiling and analysis …

Background: The human heart requires a complex ensemble of specialized cell types to
perform its essential function. A greater knowledge of the intricate cellular milieu of the heart …

Owing to the prevalence and high mortality rates of cardiac diseases, a more detailed
characterization of the human heart is necessary; however, this has been largely impeded …

Cardiovascular disease is the leading cause of death globally. An advanced understanding
of cardiovascular disease mechanisms is required to improve therapeutic strategies and …

The adult mammalian heart has limited capacity for regeneration following injury, whereas
the neonatal heart can readily regenerate within a short period after birth. Neonatal heart …

Pressure overload induces a transition from cardiac hypertrophy to heart failure, but its
underlying mechanisms remain elusive. Here we reconstruct a trajectory of cardiomyocyte …

Background: Pressure overload–induced pathological cardiac hypertrophy is a common
predecessor of heart failure, the latter of which remains a major cardiovascular disease with …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …

Cardiovascular disease is an enormous socioeconomic burden worldwide and remains a
leading cause of mortality and disability despite significant efforts to improve treatments and …