Chemokines are a class of small chemotactic molecules with cytokine-like functions, which
are well known to orchestrate inflammatory responses within different organs. Overall, more …

Chronic infection with the hepatitis C virus, a noncytopathic hepatotropic RNA virus, affects
over 170 million people worldwide. In the majority of cases, neither the early innate immune …

Double-stranded RNAs≈ 21 nucleotides long [small interfering RNA (siRNA)] are
recognized as powerful reagents to reduce the expression of specific genes. To use them as …

Background We conducted subanalyses of the combined results of the Maraviroc versus
Optimized Therapy in Viremic Antiretroviral Treatment-Experienced Patients (MOTIVATE) 1 …

We identified a novel spirodiketopiperazine (SDP) derivative, AK602/ONO4128/GW873140,
which specifically blocked the binding of macrophage inflammatory protein 1α (MIP-1α) to …

The effect of host genetic variation on the outcome of hepatitis C virus (HCV) infection and its
treatment is poorly understood. The chemokine receptors CCR5, CCR2, and CCR3 and …

Chemokines produced in the liver during hepatitis C virus (HCV) infection induce migration
of activated T cells from the periphery to infected parenchyma. The milieu of chemokines …

Infectious diseases represent a major health problem worldwide, both in terms of morbidity
and mortality. A complex combination of environmental, pathogen and host genetic factors …

BACKGROUND/AIMS: 1, 25-dihydroxyvitamin-D is involved in immunomodulation.
Expression of vitamin-D receptors in hepatocytes suggests its role in hepatocellular injury …

The interactions between chemokine receptors and their ligands may affect susceptibility to
infectious diseases as well as their clinical manifestations. These interactions mediate both …