The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

The WNT signal transduction cascade controls myriad biological phenomena throughout
development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a …

▪ Abstract Tight control of cell-cell communication is essential for the generation of a
normally patterned embryo. A critical mediator of key cell-cell signaling events during …

A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal
transduction cascade over the last two decades. Wnt genes encode small secreted proteins …

The Wnt signaling pathway is an ancient and evolutionarily conserved pathway that
regulates crucial aspects of cell fate determination, cell migration, cell polarity, neural …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

Signaling pathways are an ever present force in every animal's life. During development,
these pathways provide critical cell-cell communication required to coordinate the activities …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

Wnt signaling through the canonical β-catenin pathway plays essential roles in development
and disease. L ow-density-lipoprotein receptor-r elated p roteins 5 and 6 (Lrp5 and Lrp6) in …

A limited list of transcription factors are overactive in most human cancer cells, which makes
them targets for the development of anticancer drugs. That they are the most direct and …