The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …

Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …

Transthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is
decreased in Alzheimer's disease (AD) patients. Additionally, AD transgenic mice with only …

Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …

A non-invasive and sensitive blood test has long been a goal for early stage disease
diagnosis and treatment for Alzheimer's disease (AD) and other proteinopathy diseases. We …

Background Alzheimer's disease (AD) is a neurodegenerative disorder and is the most
common cause of late-onset dementia. Microglia, the primary innate immune cells of the …

Alzheimer's disease (AD) is a multifactorial disease with a heterogeneous etiology. The
pathology of Alzheimer's disease is characterized by amyloid-beta and …

Background The absence of transthyretin (TTR) in AD mice decreases brain Aβ clearance
and reduces the low‐density lipoprotein receptor‐related protein 1 (LRP 1). It is possible that …

Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease
(AD). We have setup a drug discovery program of small-molecule compounds that act as …

Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by
the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol …