Blood–brain-barriers in aging and in Alzheimer's disease
The aging process correlates with a progressive failure in the normal cellular and organ
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …
functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and …
Transthyretin: a multifaceted protein
M Vieira, MJ Saraiva - Biomolecular concepts, 2014 - degruyter.com
Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …
[HTML][HTML] Transthyretin participates in beta-amyloid transport from the brain to the liver-involvement of the low-density lipoprotein receptor-related protein 1?
M Alemi, C Gaiteiro, CA Ribeiro, LM Santos… - Scientific reports, 2016 - nature.com
Transthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is
decreased in Alzheimer's disease (AD) patients. Additionally, AD transgenic mice with only …
decreased in Alzheimer's disease (AD) patients. Additionally, AD transgenic mice with only …
Undiscovered roles for transthyretin: from a transporter protein to a new therapeutic target for Alzheimer's disease
T Gião, J Saavedra, E Cotrina, J Quintana… - International journal of …, 2020 - mdpi.com
Transthyretin (TTR), an homotetrameric protein mainly synthesized by the liver and the
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …
choroid plexus, and secreted into the blood and the cerebrospinal fluid, respectively, has …
Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease
S Cheng, S Banerjee, LA Daiello, A Nakashima… - Scientific reports, 2021 - nature.com
A non-invasive and sensitive blood test has long been a goal for early stage disease
diagnosis and treatment for Alzheimer's disease (AD) and other proteinopathy diseases. We …
diagnosis and treatment for Alzheimer's disease (AD) and other proteinopathy diseases. We …
Transcriptional response of murine microglia in Alzheimer's disease and inflammation
Background Alzheimer's disease (AD) is a neurodegenerative disorder and is the most
common cause of late-onset dementia. Microglia, the primary innate immune cells of the …
common cause of late-onset dementia. Microglia, the primary innate immune cells of the …
Waste clearance in the brain and neuroinflammation: a novel perspective on biomarker and drug target discovery in Alzheimer's disease
K Uchida - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is a multifactorial disease with a heterogeneous etiology. The
pathology of Alzheimer's disease is characterized by amyloid-beta and …
pathology of Alzheimer's disease is characterized by amyloid-beta and …
Transthyretin stability is critical in assisting beta amyloid clearance–Relevance of transthyretin stabilization in Alzheimer's disease
M Alemi, SC Silva, I Santana… - CNS neuroscience & …, 2017 - Wiley Online Library
Background The absence of transthyretin (TTR) in AD mice decreases brain Aβ clearance
and reduces the low‐density lipoprotein receptor‐related protein 1 (LRP 1). It is possible that …
and reduces the low‐density lipoprotein receptor‐related protein 1 (LRP 1). It is possible that …
[HTML][HTML] Targeting transthyretin in Alzheimer's disease: Drug discovery of small-molecule chaperones as disease-modifying drug candidates for Alzheimer's disease
EY Cotrina, LM Santos, J Rivas, D Blasi, JP Leite… - European Journal of …, 2021 - Elsevier
Transthyretin (TTR) has a well-established role in neuroprotection in Alzheimer's Disease
(AD). We have setup a drug discovery program of small-molecule compounds that act as …
(AD). We have setup a drug discovery program of small-molecule compounds that act as …
Transthyretin stabilization: an emerging strategy for the treatment of alzheimer's disease?
F Saponaro, JH Kim, G Chiellini - International Journal of Molecular …, 2020 - mdpi.com
Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by
the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol …
the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol …