Mechanism of drug-induced liver injury and hepatoprotective effects of natural drugs

Y Zhou, J Wang, D Zhang, J Liu, Q Wu, J Chen, P Tan… - Chinese medicine, 2021 - Springer
Drug-induced liver injury (DILI) is a common adverse drug reaction (ADR) and a serious
threat to health that affects disease treatments. At present, no targeted clinical drugs are …

[HTML][HTML] Push forward LC-MS-based therapeutic drug monitoring and pharmacometabolomics for anti-tuberculosis precision dosing and comprehensive clinical …

NQ Thu, NTN Tien, NTH Yen, TH Duong… - Journal of …, 2024 - Elsevier
The spread of tuberculosis (TB), especially multidrug-resistant TB and extensively drug-
resistant TB, has strongly motivated the research and development of new anti-TB drugs …

Prebiotic-like cyclodextrin assisted silybin on NAFLD through restoring liver and gut homeostasis

L Ren, XL Ma, HL Wang, R Li, JJ Cui, PJ Yan… - Journal of Controlled …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with no
currently approved treatment. The natural compound silybin (SLN) has versatile …

Carvacrol promotes angiogenic paracrine potential and endothelial differentiation of human mesenchymal stem cells at low concentrations

D Matluobi, A Araghi, BFA Maragheh… - Microvascular …, 2018 - Elsevier
Objectives Phenolic monoterpene compound, named Carvacrol, has been found to exert
different biological outcomes. It has been accepted that the angiogenic activity of human …

Hepatoprotective Effect of Steroidal Glycosides From Dioscorea villosa on Hydrogen Peroxide-Induced Hepatotoxicity in HepG2 Cells

MA Siddiqui, Z Ali, AG Chittiboyina… - Frontiers in …, 2018 - frontiersin.org
Dioscorea villosa, commonly known as “Wild Yam” and native to North America, is well
documented for its pharmacological properties due to the presence of steroidal glycosides …

Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response

W Zhang, L Chen, H Feng, W Wang, Y Cai, F Qi… - Free Radical Biology …, 2017 - Elsevier
Bile acid transporters and the nuclear factor erythroid 2-related factor (Nrf-2)-mediated
adaptive response play important roles in the development of drug-induced liver injury …

[HTML][HTML] Additional compounds and the therapeutic potential of Cnidoscolus chayamansa (McVaugh) against hepatotoxicity induced by antitubercular drugs

MZ Pérez-González, ML Macías-Rubalcava… - Biomedicine & …, 2019 - Elsevier
Previously non-isolated compounds (scopoletin and β-D-Glucopyranoside,(1R)-O-isopropyl
6-O-(2, 3, 4-tri-O-acetyl-β-D-xylopyranosyl)-2, 3, 4-triacetate) were isolated from an organic …

Rhizophora mucronata Lam. (Mangrove) Bark Extract Reduces Ethanol-Induced Liver Cell Death and Oxidative Stress in Swiss Albino Mice: In Vivo and In Silico …

C Jairaman, ZI Alehaideb, SAM Yacoob, SS Alghamdi… - Metabolites, 2022 - mdpi.com
The bark extract of Rhizophora mucronata (BERM) was recently reported for its prominent in
vitro protective effects against liver cell line toxicity caused by various toxicants, including …

Pentacyclic triterpenoid saponins, poterinasides A–J, from Silverweed Cinquefoil Roots promising hepatoprotective and anti-inflammatory Agents

D Yang, N Han, YW Wang, JX Zhai, ZH Liu… - The Journal of …, 2021 - ACS Publications
Silverweed cinquefoil roots, as dietary supplements, foods, and medicines, are widely used
in western areas of China, specifically in Tibet Autonomous Region and Gansu and Qinghai …

Protective Effect of Annona muricata Linn Fruit Pulp Lyophilized Powder against Paracetamol-Induced Redox Imbalance and Hepatotoxicity in Rats

S Menon, RA Al-Eisa, H Hamdi, L Lawrence… - Processes, 2023 - mdpi.com
In the current investigation, Annona muricata Linn. lyophilized fruit pulp powder was
evaluated for its hepatoprotective activity induced by paracetamol or acetaminophen …