Genomes can vary significantly even within the same individual. The underlying
mechanisms are manifold, ranging from somatic mutation and recombination, development …

All organisms encode enzymes that replicate, maintain, pack, recombine, and repair their
genetic material. For this reason, mutation rates and biases also evolve by mutation …

Cystic fibrosis (CF) is a life-threatening genetic disease characterised by chronic lung
infections sustained by opportunistic pathogens such as Pseudomonas aeruginosa. During …

Although it is well known that abundant proteins evolve slowly across the tree of life, there is
little consensus for why this is true. Here, I report that abundant proteins evolve slowly in the …

Motivation As the resolution of metagenomic analysis increases, the evolution of microbial
genomes in longitudinal metagenomic data has become a research focus. Some software …

Most cellular functions are carried out by a dynamic network of interacting proteins. An open
question is whether the network properties of protein interactomes represent phenotypes …

Selenoproteins contain the 21st amino acid, selenocysteine (Sec), which is incorporated at
select UGA codons when a specialized hairpin sequence, the Sec insertion sequence …

Abstract Bacteria, Archaea, and Eukarya all share a common set of metabolic reactions. This
implies that the function and topology of central metabolism has been evolving under …