Melanomas on sun-exposed skin are heterogeneous tumours, which can be subtyped on
the basis of their cumulative levels of exposure to ultraviolet (UV) radiation. A melanocytic …

Melanoma is a cancer that exhibits one of the most aggressive and heterogeneous features.
The incidence rate escalates. A high number of clones harboring various mutations …

Melanoma and nonmelanoma skin cancer (NMSC) are now the most common types of
cancer in white populations. Both tumor entities show an increasing incidence rate …

The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and
the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell …

Purpose To describe the emergence of targeted therapies that have led to significant
breakthroughs in cancer therapy and completed or ongoing clinical trials of novel agents for …

Melanoma is one of the most highly mutated malignancies, largely as a function of its
generation through ultraviolet light and other mutational processes. The wide array of …

Episodic exposure of fair-skinned individuals to intense sunlight is thought to be responsible
for the steadily increasing melanoma incidence worldwide over recent decades. Rarely …

Background There have been conflicting data regarding the prevalence and
clinicopathological characteristics of BRAF and NRAS mutations in primary cutaneous …

Melanocytic nevi are a benign clonal proliferation of cells expressing the melanocytic
phenotype, with heterogeneous clinical and molecular characteristics. In this review, we …

Purpose: Recently, it was reported that BRAF mutations are frequent in melanoma.
Previously, we analyzed a large series of paired primary and metastatic melanomas for …