The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an
endopeptidase activity. Although its primary functions were originally thought to be only of a …

Over the past two decades, deadly coronaviruses, with the most recent being the severe
acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) 2019 pandemic, have …

Proteolysis of eukaryotic histone tails has emerged as an important factor in the modulation
of cell-cycle progression and cellular differentiation. The recruitment of lysosomal cathepsin …

The protozoan parasite Toxoplasma gondii relies on post-translational modification,
including proteolysis, of proteins required for recognition and invasion of host cells. We have …

Emerging RNA viruses, including SARS-CoV-2, continue to be a major threat. Cell entry of
SARS-CoV-2 particles via the endosomal pathway involves cysteine cathepsins. Due to …

High levels of cathepsins indicated in various pathological conditions like arthritis, cancer
progressions, and atherosclerosis explains the need to explore potential inhibitors of these …

Abstract Cathepsin B [EC 3.4. 22.1], cathepsin H [EC 3.4. 22.16] and cathepsin L [EC 3.4.
22.15] are the most versatile lysosomal cysteine proteases and are responsible for …

In this paper we present the design, synthesis, and biological evaluation of a new series of
peptidomimetics acting as potent anti-SARS-CoV-2 agents. Starting from our previously …

Cathepsin L plays a key role in many pathophysiological conditions including rheumatoid
arthritis, tumor invasion and metastasis, bone resorption and remodeling. Here we report the …