Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Eradicating tumor dormancy that develops following epidermal growth factor receptor
(EGFR) tyrosine kinase inhibitor (TKI) treatment of EGFR-mutant non-small cell lung cancer …

Introduction Tissues can be soft like brain, bone marrow, and fat, which bear little
mechanical stress, or stiff like muscle, cartilage, and bone, which sustain high levels of …

The initiation of osteogenesis primarily occurs as mesenchymal stem cells undergo
differentiation into osteoblasts. This differentiation process plays a crucial role in bone …

Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Background: The transcription factor BACH1 (BTB and CNC homology 1) suppressed
endothelial cells (ECs) proliferation and migration and impaired angiogenesis in the …

Studies over the past 20 years have defined the Hippo signaling pathway as a major
regulator of tissue growth and organ size. Diverse roles for the Hippo pathway have …

The Hippo pathway is involved in the regulation of contact inhibition of proliferation and
responses to various physical and chemical stimuli. Recently, several upstream negative …

Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers;
emerging evidence indicates that oncogenic β-catenin regulates several biological …