Narcolepsy is a rare brain disorder that reflects a selective loss or dysfunction of orexin (also
known as hypocretin) neurons of the lateral hypothalamus. Narcolepsy type 1 (NT1) is …

The opioid crisis in the United States has brought drug addiction to the forefront of the public
mind and to the attention of health care personnel, organizations, and agencies. The …

Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic
neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune …

Increased orexin/hypocretin signaling is implicated in opioid withdrawal, sleep disturbances,
and drug-seeking behaviors. This study examined whether a dual-orexin receptor …

Neural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS
(NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with …

The neurobiology of sleep and substance abuse interconnects, such that alterations in one
process have consequences for the other. Acute exposure to drugs of abuse disrupts sleep …

The orexin (hypocretin) system plays a critical role in motivated drug taking. Cocaine self‐
administration with the intermittent access (IntA) procedure produces a robust addiction‐like …

Millions of Americans suffer from opiate use disorder, and over 100 die every day from
opioid overdoses. Opioid use often progresses into a vicious cycle of abuse and withdrawal …

In 2014, we proposed that orexin signaling transformed motivationally relevant states into
adaptive behavior directed toward exploiting an opportunity or managing a threat, a process …

It has been proposed that binge eating reflects a pathological compulsion driven by the
“addictive” properties of foods. Proponents of this argument highlight the large degree of …