Artificial intelligence, machine learning, and drug repurposing in cancer
Z Tanoli, M Vähä-Koskela… - Expert opinion on drug …, 2021 - Taylor & Francis
Introduction: Drug repurposing provides a cost-effective strategy to re-use approved drugs
for new medical indications. Several machine learning (ML) and artificial intelligence (AI) …
for new medical indications. Several machine learning (ML) and artificial intelligence (AI) …
Modern pharmacological treatment of obese patients
M May, C Schindler, S Engeli - Therapeutic advances in …, 2020 - journals.sagepub.com
There are many angles to consider in drug treatment of obese patients. On the one hand,
some specific weight loss drugs are available, on the other, several drugs are associated …
some specific weight loss drugs are available, on the other, several drugs are associated …
[HTML][HTML] Understanding the relevance of herb–drug interaction studies with special focus on interplays: a prerequisite for integrative medicine
SP Borse, DP Singh, M Nivsarkar - Porto Biomedical Journal, 2019 - journals.lww.com
Integrative medicine refers to the blending of conventional and evidence-based
complementary medicines and therapies with the aim of using the most appropriate of either …
complementary medicines and therapies with the aim of using the most appropriate of either …
Association between plasma concentrations of certolizumab pegol and endoscopic outcomes of patients with Crohn's disease
JF Colombel, WJ Sandborn, M Allez, JL Dupas… - Clinical …, 2014 - Elsevier
Background & Aims Monitoring plasma concentrations of anti–tumor necrosis factor agents
could optimize treatment of patients with Crohn's Disease (CD). In a post hoc analysis of …
could optimize treatment of patients with Crohn's Disease (CD). In a post hoc analysis of …
Identification of hub biomarkers and immune-related pathways participating in the progression of antineutrophil cytoplasmic antibody-associated glomerulonephritis
MD Xia, RR Yu, DM Chen - Frontiers in Immunology, 2022 - frontiersin.org
Background Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a
systemic autoimmune disease that generally induces the progression of rapidly progressive …
systemic autoimmune disease that generally induces the progression of rapidly progressive …
Role of genetic polymorphisms in drug-metabolizing enzyme-mediated toxicity and pharmacokinetic resistance to anti-cancer agents: a review on the …
The inter-individual differences in cancer susceptibility are somehow correlated with the
genetic differences that are caused by the polymorphisms. These genetic variations in drug …
genetic differences that are caused by the polymorphisms. These genetic variations in drug …
Transporters in the mammary gland—contribution to presence of nutrients and drugs into milk
AM García-Lino, I Álvarez-Fernández… - Nutrients, 2019 - mdpi.com
A large number of nutrients and bioactive ingredients found in milk play an important role in
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …
Potential role of drug metabolizing enzymes in chemotherapy-induced gastrointestinal toxicity and hepatotoxicity
Introduction Toxicity of chemotherapy drugs is the leading cause of poor therapeutic
outcome in many cancer patients. Gastrointestinal (GI) toxicity and hepatotoxicity are among …
outcome in many cancer patients. Gastrointestinal (GI) toxicity and hepatotoxicity are among …
Cytochrome P450s: mechanisms and biological implications in drug metabolism and its interaction with oxidative stress
Background: Cytochrome monooxygenases P450 enzymes (CYPs) are terminal oxidases,
belonging to the multi-gene family of heme-thiolate enzymes and located in multiple sites of …
belonging to the multi-gene family of heme-thiolate enzymes and located in multiple sites of …
Nonalcoholic fatty liver disease (NAFLD) and hepatic cytochrome P450 (CYP) enzymes
R Jamwal, BJ Barlock - Pharmaceuticals, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat in the liver. An
international consensus panel has recently proposed to rename the disease to metabolic …
international consensus panel has recently proposed to rename the disease to metabolic …