Sex disparities matter in cancer development and therapy
Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …
molecular and genomic therapies. Currently, whether patients with non-reproductive …
[HTML][HTML] Primary Undifferentiated/Dedifferentiated Cutaneous Melanomas—A Review on Histological, Immunohistochemical, and Molecular Features with Emphasis …
DA Țăpoi, AA Gheorghișan-Gălățeanu… - International Journal of …, 2023 - mdpi.com
Diagnosing cutaneous melanoma is usually straightforward based on these malignancies'
histopathological and immunohistochemical features. Nevertheless, melanomas can imitate …
histopathological and immunohistochemical features. Nevertheless, melanomas can imitate …
[HTML][HTML] Escape from X-inactivation in twins exhibits intra-and inter-individual variability across tissues and is heritable
A Zito, AL Roberts, A Visconti, N Rossi… - PLoS …, 2023 - journals.plos.org
X-chromosome inactivation (XCI) silences one X in female cells to balance sex-differences
in X-dosage. A subset of X-linked genes escape XCI, but the extent to which this …
in X-dosage. A subset of X-linked genes escape XCI, but the extent to which this …
[HTML][HTML] Lysine demethylases: promising drug targets in melanoma and other cancers
Epigenetic dysregulation has been implicated in a variety of pathological processes
including carcinogenesis. A major group of enzymes that influence epigenetic modifications …
including carcinogenesis. A major group of enzymes that influence epigenetic modifications …
[HTML][HTML] KDM6 demethylases and their roles in human cancers
C Hua, J Chen, S Li, J Zhou, J Fu, W Sun… - Frontiers in …, 2021 - frontiersin.org
Cancer therapy is moving beyond traditional chemotherapy to include epigenetic
approaches. KDM6 demethylases are dynamic regulation of gene expression by histone …
approaches. KDM6 demethylases are dynamic regulation of gene expression by histone …
[HTML][HTML] Revisiting miRNA association with melanoma recurrence and metastasis from a machine learning point of view
The diagnostic and prognostic value of miRNAs in cutaneous melanoma (CM) has been
broadly studied and supported by advanced bioinformatics tools. From early studies using …
broadly studied and supported by advanced bioinformatics tools. From early studies using …
[HTML][HTML] A novel signature of 23 immunity-related gene pairs is prognostic of cutaneous melanoma
YN Xue, YN Xue, ZC Wang, YZ Mo, PY Wang… - Frontiers in …, 2020 - frontiersin.org
In this study, we aimed to identify an immune-related signature for predicting prognosis in
cutaneous melanoma (CM). Sample data from The Cancer Genome Atlas (TCGA; n= 460) …
cutaneous melanoma (CM). Sample data from The Cancer Genome Atlas (TCGA; n= 460) …
[HTML][HTML] A combination of epigenetic BET and CDK9 inhibitors for treatment of human melanoma
A Al Emran, HY Tseng, D Gunatilake, SJ Cook… - Journal of Investigative …, 2021 - Elsevier
Dysregulation of epigenetic modifiers is a frequent event in melanoma and underlies many
aspects of melanoma biology, including resistance to targeted therapy and …
aspects of melanoma biology, including resistance to targeted therapy and …
Sex bias of females in survival from cancer and infections. Is X the answer?
Major differences in survival of men and women from infectious diseases and cancers have
been highlighted by death rates from COVID-19 infections. In cancer, attention has been …
been highlighted by death rates from COVID-19 infections. In cancer, attention has been …
[HTML][HTML] Comprehensive gene expression analysis to identify differences and similarities between sex-and stage-stratified melanoma samples
Overall lower incidence and better prognosis are observed in female melanoma patients
compared to males. As sex and stage differences in the context of melanoma gene …
compared to males. As sex and stage differences in the context of melanoma gene …