Almost half of the human genome is made up of transposable elements (TEs), and about 8%
consists of endogenous retroviruses (ERVs). ERVs are remnants of ancient exogenous …

Transposable Elements (TE) are mobile DNA elements that can replicate and insert
themselves into different locations within the host genome. Their propensity to self …

Abstract The Sequence Read Archive (SRA, https://www. ncbi. nlm. nih. gov/sra/) stores raw
sequencing data and alignment information to enhance reproducibility and facilitate new …

Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for
which whole-genome and—for a subset—whole-transcriptome sequencing data from 2,658 …

We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in
cancer through the viral defense pathway. In ovarian cancer (OC), DNMTis trigger cytosolic …

HIV-1 proviruses persist in the CD4+ T cells of HIV-infected individuals despite years of
combination antiretroviral therapy (cART) with suppression of HIV-1 RNA levels< 40 …

Detection of nucleic acids and induction of type I interferons (IFNs) are principal elements of
antiviral defense but can cause autoimmunity if misregulated. Cytosolic DNA detection …

Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in
cancers, yet their activity in nondiseased tissue is largely unknown. Using the GTEx RNA …

The anti-viral pattern recognition receptor STING and its partnering cytosolic DNA sensor
cGAS have been increasingly recognized to respond to self DNA in multiple pathologic …

Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable
elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make …