The detailed understanding of chemical reactions still represents a major challenge for
experimental as well as theoretical chemists. The enormous progress in both hard-and …

The development of anticancer drugs started over four decades ago, with the serendipitous
discovery of the antitumor activity of cisplatin and its successful use in the treatment of …

The effect of different N− N spectator ligands on the reactivity of platinum (II) complexes was
investigated by studying the water lability of [Pt (diaminocyclohexane)(H2O) 2] 2+(Pt …

Interactions of hydrated cisplatin complexes with sulphur-containing amino acids cysteine
and methionine were explored. The square-planar cis-[Pt (NH3) 2 (H2O) X]+ complexes …

The thermodynamic and kinetic aspects of hydration reactions of cis‐/transplatin were
explored. The polarizable continuum model was used for estimation of solvent effects. Using …

In this study, the interaction of 5-fluorouracil (5FU) drug with adenine (A), guanine (G),
cytosine (C), uracil (U), and thymine (T) nucleobases of DNA and RNA are surveyed at the …

Abstract Cisplatin [cis‐diamminedichloroplatinum (II)] was the first platinum‐based
antineoplastic agent and is still a cornerstone for the treatment of various solid tumors …

The complexes Pt (pq) Cl2 (1) and Pt (pq)(bdt)(2)(where pq= 2-(2′ pyridyl) quinoxaline and
bdt= benzene-1, 2-dithiolate) have been synthesized and fully characterized by UV–visible …

A mononuclear complex Pt (pq)(bdt)(1)(where pq= 2-(2′ pyridyl) quinoxaline and bdt=
benzene-1, 2-dithiolate) has been prepared and characterized by NMR spectroscopy, ES …

The Lennard-Jones (12− 6) parameters were obtained for all atoms of cisplatin molecule
using the ab initio quantum mechanical potential energy surface for the water− cisplatin …