Objectives Firstly, to identify subthalamic region stimulation clusters that predict maximum
improvement in rigidity, bradykinesia and tremor, or emergence of side-effects; and …

Several single-center studies and one large multicenter clinical trial demonstrated that
directional deep brain stimulation (DBS) could optimize the volume of tissue activated (VTA) …

Optogenetics is an invasive neuromodulation technology involving the use of light to control
the activity of individual neurons. Even though optogenetics is a relatively new …

Background Deep brain stimulation (DBS) is an established clinical therapy and
computational models have played an important role in advancing the technology. Patient …

Medical imaging has played a major role in defining the general anatomical targets for deep
brain stimulation (DBS) therapies. However, specifics on the underlying brain circuitry that is …

Objective Subthalamic deep brain stimulation (DBS) is an established therapy for
Parkinson's disease. Connectomic DBS modeling is a burgeoning subfield of research …

Subcallosal cingulate (SCC) deep brain stimulation (DBS) is an emerging therapy for
refractory depression. Good clinical outcomes are associated with the activation of white …

Abstract Background High frequency (∼ 130 Hz) deep brain stimulation (DBS) of the
subthalamic region is an established clinical therapy for the treatment of late stage …

We present a data-driven workflow to biological tissue modeling, which aims to predict the
displacement field based on digital image correlation (DIC) measurements under unseen …

In this study, we propose a new open-source simulation platform that comprises computer-
aided design and computer-aided engineering tools for highly automated evaluation of …