Pathogen at the gates: human cytomegalovirus entry and cell tropism
The past few years have brought substantial progress toward understanding how human
cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that …
cytomegalovirus (HCMV) enters the remarkably wide spectrum of cell types and tissues that …
Human cytomegalovirus: taking the strain
GWG Wilkinson, AJ Davison, P Tomasec… - Medical microbiology …, 2015 - Springer
In celebrating the 60th anniversary of the first isolation of human cytomegalovirus (HCMV),
we reflect on the merits and limitations of the viral strains currently being used to develop …
we reflect on the merits and limitations of the viral strains currently being used to develop …
Human cytomegalovirus glycoprotein complex gH/gL/gO uses PDGFR-α as a key for entry
Herpesvirus gH/gL envelope glycoprotein complexes are key players in virus entry as
ligands for host cell receptors and by promoting fusion of viral envelopes with cellular …
ligands for host cell receptors and by promoting fusion of viral envelopes with cellular …
Human cytomegalovirus gH/gL/gO promotes the fusion step of entry into all cell types, whereas gH/gL/UL128-131 broadens virus tropism through a distinct …
M Zhou, JM Lanchy, BJ Ryckman - Journal of virology, 2015 - Am Soc Microbiol
Interaction between gH/gL and the fusion protein gB is likely a conserved feature of the entry
mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by …
mechanism for all herpesviruses. Human cytomegalovirus (HCMV) gH/gL can be bound by …
Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies
Human cytomegalovirus (HCMV) encodes multiple surface glycoprotein complexes to infect
a variety of cell types. The HCMV Pentamer, composed of gH, gL, UL128, UL130, and …
a variety of cell types. The HCMV Pentamer, composed of gH, gL, UL128, UL130, and …
The pentameric complex drives immunologically covert cell–cell transmission of wild-type human cytomegalovirus
I Murrell, C Bedford, K Ladell… - Proceedings of the …, 2017 - National Acad Sciences
Human cytomegalovirus (HCMV) strains that have been passaged in vitro rapidly acquire
mutations that impact viral growth. These laboratory-adapted strains of HCMV generally …
mutations that impact viral growth. These laboratory-adapted strains of HCMV generally …
HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation
VM Vlachava, S Seirafian, CA Fielding… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (HCMV) is a paradigm of pathogen immune evasion and sustains
lifelong persistent infection in the face of exceptionally powerful host immune responses …
lifelong persistent infection in the face of exceptionally powerful host immune responses …
The roles of host and viral antibody fc receptors in herpes simplex virus (HSV) and human cytomegalovirus (HCMV) infections and immunity
Herpesvirus infections are a leading cause of neurodevelopmental delay in newborns and
end-organ disease in immunocompromised patients. One leading strategy to reduce the …
end-organ disease in immunocompromised patients. One leading strategy to reduce the …
A viral regulator of glycoprotein complexes contributes to human cytomegalovirus cell tropism
Viral glycoproteins mediate entry of enveloped viruses into cells and thus play crucial roles
in infection. In herpesviruses, a complex of two viral glycoproteins, gH and gL (gH/gL) …
in infection. In herpesviruses, a complex of two viral glycoproteins, gH and gL (gH/gL) …
Genomic and functional characteristics of human cytomegalovirus revealed by next-generation sequencing
The complete genome of human cytomegalovirus (HCMV) was elucidated almost 25 years
ago using a traditional cloning and Sanger sequencing approach. Analysis of the genetic …
ago using a traditional cloning and Sanger sequencing approach. Analysis of the genetic …