Key Clinical Points Obstructive Sleep Apnea in Adults Obstructive sleep apnea is common
and is an independent risk factor for motor vehicle accidents and cardiovascular disease …

Abstract Purpose of Review Given the rising prevalence of obstructive sleep apnea (OSA),
we aimed to review the epidemiologic and pathophysiologic relationship of OSA …

Importance Obesity is the leading cause of obstructive sleep apnea (OSA); however, the
effects of weight loss and lifestyle interventions on OSA and comorbidities remain uncertain …

Recent studies have demonstrated that obstructive sleep apnea (OSA) is associated with the
development and evolution of nonalcoholic fatty liver disease (NAFLD), independent of …

Emerging evidence has assigned an important role to sleep as a modulator of metabolic
homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and …

Synchronization of molecular, metabolic, and cardiovascular circadian oscillations is
fundamental to human health. Sleep-disordered breathing, which disrupts such temporal …

Insufficient sleep, which has become endemic in recent years, has been variably associated
with increased risk of obesity, disorders of glucose and insulin homeostasis, and the …

Obstructive sleep apnea (OSA) is a prevalent, underdiagnosed disease that imposes a
significant impact on the health and wellbeing of patients and a financial burden on …

Lipid metabolism deregulation constitutes the pathogenic basis for the development of
atherosclerosis and justifies a high incidence of cardiovascular-related morbidity and …

Obstructive sleep apnea (OSA) is characterized by upper airway collapse during sleep.
Chronic intermittent hypoxia, sleep fragmentation, and inflammatory activation are the main …