Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

The initial discovery that ob/ob mice become obese because of a recessive mutation of the
leptin gene has been crucial to discover the melanocortin pathway to control appetite. In the …

Leptin is secreted into the bloodstream by adipocytes and is required for the maintenance of
energy homeostasis and body weight. Leptin deficiency or genetic defects in the …

The 'obesity epidemic'represents a major global socioeconomic burden that urgently calls
for a better understanding of the underlying causes of increased weight gain and its …

With the steady rise in the prevalence of obesity and its associated diseases, research
aimed at understanding the mechanisms that regulate and control whole body energy …

Summary Interleukin (IL)-6 engages similar signaling mechanisms to leptin. Here, we find
that central application of IL-6 in mice suppresses feeding and improves glucose tolerance …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …

The regulation of body fat stores and blood glucose levels is critical for survival. This review
highlights growing evidence that leptin action in the central nervous system plays a key role …

Obesity has been characterized as a state of chronic inflammation. Inflammatory signaling
not only causes peripheral insulin resistance, but also promotes neuronal insulin and leptin …