Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

Liver fibrosis is characterized by the excessive deposition and accumulation of extracellular
matrix components, mainly collagens, and occurs in response to a broad spectrum of …

Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from
damaged organelles and other cellular components through lysosomal degradation …

Upon activation by RAS, RAF family kinases initiate signaling through the MAP kinase
cascade to control cell growth, proliferation, and differentiation. Among RAF isoforms (ARAF …

The human brain has high energetic expenses and consumes over 20% of total oxygen
metabolism. Abnormal brain energy homeostasis leads to various brain diseases. Among …

CK1s are acidophilic serine/threonine kinases with multiple critical cellular functions; their
misregulation contributes to cancer, neurodegenerative diseases, and sleep phase …

Serine/threonine-protein kinases 3 and 4 (STK3 and STK4, respectively) are key
components of the Hippo signaling pathway, which regulates cell proliferation and death …

Autophagy can play a double role in cancerogenesis: it can either inhibit further
development of the disease or protect cells, causing stimulation of tumour growth. This …

Many cancers, including pancreatic ductal adenocarcinoma (PDAC), depend on autophagy-
mediated scavenging and recycling of intracellular macromolecules, suggesting that …