Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …

Lung cancer stands as the primary contributor to cancer-related fatalities worldwide,
affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC) …

As a permanent state of cell cycle arrest, cellular senescence has become an important
factor in aging and age-related diseases. As a central regulator of physiology and pathology …

Simple Summary Despite multi-modal treatment consisting of surgery, chemotherapy, and
radiation, glioblastoma inevitably recurs due to its diffuse infiltrative nature. Anti-tumor …

Simple Summary Liver metastasis is a significant factor contributing to mortality associated
with colorectal cancer. Establishing the biological mechanisms of metastasis is crucial for …

Older patients with cancer, particularly those over 75 years of age, often experience poorer
clinical outcomes compared to younger patients. This can be attributed to age-related …

Simple Summary The development of targeted therapies has led to personalized medicine
for advanced non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma …

The ageing phenotype is strongly driven by the exhaustion of adult stem cells (ASCs) and
the accumulation of senescent cells. Cardiovascular diseases (CVDs) and heart failure (HF) …

Fibroblasts are abundant stromal cells which not only control the integrity of extracellular
matrix (ECM) but also act as immune regulators. It is known that the structural cells within …

The accumulation of pro-inflammatory senescent cells within tissues is a common hallmark
of the aging process and many age-related diseases. This modification has been called the …