The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Highlights•Two recent crystal structures show how DM interacts with MHCII proteins.•Studies
of H2-O knockout mice reveal a role for DO in regulating immunity and autoimmunity.•Key …

HLA-DM mediates the exchange of peptides loaded onto MHCII molecules during antigen
presentation by a mechanism that remains unclear and controversial. Here, we investigated …

Introduction: Most elapid snakes produce venoms that contain alpha-neurotoxins (α-NTXs),
which are proteins that cause post-synaptic blockade and paralysis in snakebite …

During the adaptive immune response, MHCII proteins display antigenic peptides on the cell
surface of APCs for CD4+ T cell surveillance. HLA-DM, a nonclassical MHCII protein, acts as …

Major histocompatibility complex (MHC) class II molecules are expressed by antigen‐
presenting cells and stimulate CD 4+ T cells, which initiate humoral immune responses …

The interaction between T cell receptor (TCR) and peptide (p)-Human Leukocyte Antigen
(HLA) complexes is the critical first step in determining T cell responses. X-ray …

Abstract The West Nile virus (WNV) is the causative agent of West Nile disease (WND),
which poses a potential risk of meningitis or encephalitis. The aim of the study was to design …

B cells internalize extracellular Ag into endosomes using the Ig component of the BCR. In
endosomes, Ag-derived peptides are loaded onto MHC class II proteins. How these …

Human leukocyte antigen-DM (HLA-DM) is an integral component of the major
histocompatibility complex class II (MHCII) antigen-processing and-presentation pathway …