Aberrant gene expression lies at the heart of many pathologies. This review will point out
how 3′ end processing, the final mRNA-maturation step in the transcription cycle, is …

Extensive research into gene fusions in cancer and other diseases has led to the discovery
of novel biomarkers and therapeutic targets. Concurrently, various bioinformatics tools have …

The cytochrome P450s enzyme family metabolizes∼ 80% of small molecule drugs. Variants
in cytochrome P450s can substantially alter drug metabolism, leading to improper dosing …

Introduction NBS-LRR genes (NLRs) are the most extensive category of plant resistance
genes (R genes) and play a crucial role in pathogen defense. Understanding the diversity …

Arising as co-products of canonical gene expression, transcription-associated lincRNAs,
such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and …

Our prior research has effectively developed tissue-engineered vascularized oral mucosa
equivalents (VOME); however, challenges such as low repeatability and stability, as well as …

Radiation therapy represents the primary treatment option for triple-negative breast cancer.
However, radio resistance is associated with a poor prognosis and an increased risk of …

The crab-eating macaques (Macaca fascicularis) and rhesus macaques (M. mulatta) are
widely studied nonhuman primates in biomedical and evolutionary research. Despite their …

During DNA-involving processes such as transcription and replication the double helix is
subjected to torsional stress. The over-or under-winding that encompasses torsional stress …