Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into
humans, causing highly prevalent and severe respiratory diseases, often with fatal …

Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal
function. Accordingly, transformation and cancer progression are characterized by dramatic …

Uncontrolled microglial activation is pivotal to the pathogenesis of Parkinson's disease (PD),
which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; …

Cysteine cathepsins (CTS), being involved in both physiological and pathological
processes, play an important role in the human body. During the last 30 years, it has been …

A significant proportion of breast cancer patients harbor clinically undetectable
micrometastases at the time of diagnosis. If left untreated, these micro-metastases may lead …

It is estimated that approximately 90% of patients with advanced prostate cancer develop
bone metastases; an occurrence that results in a substantial reduction in the quality of life …

The activation of endothelial cells by oxidized low-density lipoprotein (ox-LDL) with
subsequent increases in endothelial permeability occurs in the early stage of …

Proteolytic activity is required for several key processes in cancer development and
progression, including tumor growth, invasion and metastasis. Accordingly, high levels of …

Background Probiotics have gained exponential attention worldwide because they are used
as a therapeutic tool for management, prevention and treatment of diseases like cancer …

Epithelial ovarian cancer (EOC) metastasizes transcoelomically to the peritoneum and
omentum, and despite surgery and chemotherapy, recurrent disease is likely. Metastasis …