The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors
A Pišlar, A Mitrović, J Sabotič, U Pečar Fonović… - PLoS …, 2020 - journals.plos.org
Over the last 2 decades, several coronaviruses (CoVs) have crossed the species barrier into
humans, causing highly prevalent and severe respiratory diseases, often with fatal …
humans, causing highly prevalent and severe respiratory diseases, often with fatal …
Cancer-associated lysosomal changes: friends or foes?
T Kallunki, OD Olsen, M Jäättelä - Oncogene, 2013 - nature.com
Rapidly dividing and invasive cancer cells are strongly dependent on effective lysosomal
function. Accordingly, transformation and cancer progression are characterized by dramatic …
function. Accordingly, transformation and cancer progression are characterized by dramatic …
Cathepsin L-containing exosomes from α-synuclein-activated microglia induce neurotoxicity through the P2X7 receptor
T Jiang, C Xu, S Gao, J Zhang, J Zheng, X Wu… - NPJ Parkinson's …, 2022 - nature.com
Uncontrolled microglial activation is pivotal to the pathogenesis of Parkinson's disease (PD),
which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; …
which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; …
Cysteine cathepsins as a prospective target for anticancer therapies—current progress and prospects
A Pogorzelska, B Żołnowska, R Bartoszewski - Biochimie, 2018 - Elsevier
Cysteine cathepsins (CTS), being involved in both physiological and pathological
processes, play an important role in the human body. During the last 30 years, it has been …
processes, play an important role in the human body. During the last 30 years, it has been …
Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94
DR Sudhan, MB Rabaglino, CE Wood… - Clinical & experimental …, 2016 - Springer
A significant proportion of breast cancer patients harbor clinically undetectable
micrometastases at the time of diagnosis. If left untreated, these micro-metastases may lead …
micrometastases at the time of diagnosis. If left untreated, these micro-metastases may lead …
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model
DR Sudhan, C Pampo, L Rice… - International journal of …, 2016 - Wiley Online Library
It is estimated that approximately 90% of patients with advanced prostate cancer develop
bone metastases; an occurrence that results in a substantial reduction in the quality of life …
bone metastases; an occurrence that results in a substantial reduction in the quality of life …
[HTML][HTML] Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis
DH Wei, XY Jia, YH Liu, FX Guo… - International …, 2013 - spandidos-publications.com
The activation of endothelial cells by oxidized low-density lipoprotein (ox-LDL) with
subsequent increases in endothelial permeability occurs in the early stage of …
subsequent increases in endothelial permeability occurs in the early stage of …
Identification and pre-clinical testing of a reversible cathepsin protease inhibitor reveals anti-tumor efficacy in a pancreatic cancer model
Proteolytic activity is required for several key processes in cancer development and
progression, including tumor growth, invasion and metastasis. Accordingly, high levels of …
progression, including tumor growth, invasion and metastasis. Accordingly, high levels of …
Lactobacillus acidophilus and Bifidobacterium longum exhibit antiproliferation, anti-angiogenesis of gastric and bladder cancer: Impact of COX2 inhibition
Background Probiotics have gained exponential attention worldwide because they are used
as a therapeutic tool for management, prevention and treatment of diseases like cancer …
as a therapeutic tool for management, prevention and treatment of diseases like cancer …
Epithelial ovarian cancer-induced angiogenic phenotype of human omental microvascular endothelial cells may occur independently of VEGF signaling
BK Winiarski, KI Wolanska, S Rai, T Ahmed… - Translational …, 2013 - Elsevier
Epithelial ovarian cancer (EOC) metastasizes transcoelomically to the peritoneum and
omentum, and despite surgery and chemotherapy, recurrent disease is likely. Metastasis …
omentum, and despite surgery and chemotherapy, recurrent disease is likely. Metastasis …