Looked at from the genetic point-of-view cancer represents a daunting and, frankly,
confusing multiplicity of diseases (at least 100) that require an equally large variety of …

This review article considers the purposes and mechanisms of regulation of placental
transfer in general terms and then illustrates some key points with reference to the Na+/H+ …

Mutations in the SLC13A5 gene that codes for the Na+/citrate cotransporter, NaCT, are
associated with early onset epilepsy, developmental delay and tooth dysplasia in children …

In triple-negative breast cancer (TNBC), the high recurrence rate, increased invasion and
aggressive metastatic formation dictate patient survival. We previously demonstrated a …

Plasma membrane Cl-/HCO3-anion-exchange (AE) proteins contribute to regulation of
intracellular pH (pHi). We characterized the transport activity and regulation by pHi of full …

The NHE1 isoform of the Na+/H+ exchanger is a ubiquitous plasma membrane protein that
regulates intracellular pH in mammalian cells. Site‐specific mutagenesis was used to …

The plant plasma membrane Na+/H+ antiporter SOS1 (Salt Overlay Sensitive 1) of
Arabidopsis thaliana is the major transporter extruding Na+ out of cells in exchange for an …

Human NBC3 is an electroneutral Na+/HCO3− cotransporter expressed in heart, skeletal
muscle, and kidney in which it plays an important role in HCO3− metabolism. Cytosolic …

NHE3, the apical isoform of the Na+/H+ exchanger, is central to the absorption of salt and
water across the intestinal epithelium. We report that treatment of epithelial cells with toxin B …

The activity of the Na+/H+ exchanger has been implicated as an important contributing factor
in damage to the myocardium that occurs during ischemia and reperfusion. We examined …